{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:21:55Z","timestamp":1767705715729},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T00:00:00Z","timestamp":1422662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["81271118"],"award-info":[{"award-number":["81271118"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010syndromic orofacial clefts (<jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>s) are complex disease involving genetic triggers, environmental factors, and their interplay. Recent studies demonstrated that <jats:italic><jats:styled-content style=\"fixed-case\">EYA<\/jats:styled-content>1<\/jats:italic>, a member of eye absent gene family, might contribute to <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated three single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) and eight environmental factors (multivitamin, folic acid and calcium supplementation history, maternal alcohol consumption, common cold history, maternal smoking and environmental tobacco smoke in the first trimester, and paternal smoking in the 3\u00a0months before pregnancy) among 294 case\u2013parent trios and 183 individual controls in western Han Chinese to evaluate the relationship between <jats:italic><jats:styled-content style=\"fixed-case\">EYA<\/jats:styled-content>1<\/jats:italic>, environmental factors, and <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>s. To be better known the gene's role in the etiology of <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>s, we performed statistical analysis in different aspects including the linkage disequilibrium test, transmission disequilibrium test, haplotype analysis, multiple logistic regression analysis, and conditional logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Allele C at rs3779748 showed an over\u2010transmission in <jats:styled-content style=\"fixed-case\">NSCL<\/jats:styled-content>\/P trios (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), and genotype A\/A at rs10094908 was under\u2010transmitted among <jats:styled-content style=\"fixed-case\">NSCL<\/jats:styled-content>\/P trios (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), whereas over\u2010transmitted among <jats:styled-content style=\"fixed-case\">NSCPO<\/jats:styled-content> trios (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). The haplotype <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> of rs10094908\u2013rs3779748 was over\u2010transmitted among <jats:styled-content style=\"fixed-case\">NSCL<\/jats:styled-content>\/P trios (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05) and <jats:styled-content style=\"fixed-case\">NSCPO<\/jats:styled-content> trios (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05), respectively. Maternal common cold history, environmental tobacco smoke, and maternal alcohol consumption during the first trimester of pregnancy were risk factors for <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>s, while calcium supplementation during the first trimester showed a protective effect. No evidence of interactions between <jats:italic><jats:styled-content style=\"fixed-case\">EYA<\/jats:styled-content>1<\/jats:italic> and environmental factors was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results revealed an association between <jats:italic><jats:styled-content style=\"fixed-case\">EYA<\/jats:styled-content>1<\/jats:italic>, some environmental factors, and <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>s in western Han Chinese.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12311","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T06:52:38Z","timestamp":1422687158000},"page":"864-869","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of the association of polymorphisms in <i><scp>EYA<\/scp>1<\/i>, environmental factors, and non\u2010syndromic orofacial clefts in Western Han Chinese"],"prefix":"10.1111","volume":"44","author":[{"given":"Ni","family":"Zeng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China"},{"name":"Department of Cleft Lip and Palate Surgery West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China"},{"name":"Department of Cleft Lip and Palate Surgery West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Chao","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China"},{"name":"Department of Cleft Lip and Palate Surgery West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China"},{"name":"Department of Cleft Lip and Palate Surgery West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong\u2010Lin","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China"},{"name":"Department of Cleft Lip and Palate Surgery West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01588.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4248\/IJOS10047"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-007-9129-y"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700202"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000185138.65820.7f"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8817.2005.00204.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44630"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2010.1082"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1039"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1996)13:5<423::AID-GEPI1>3.0.CO;2-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60695-4"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02083"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/12722"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31965"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2007.10.004"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700180200"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.245"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2007.00947.x"},{"key":"e_1_2_5_21_1","first-page":"128","article-title":"Branchio\u2010oculo\u2010facial syndrome: case report","volume":"22","author":"Lin JL","year":"1999","journal-title":"Changgeng Yi Xue Za Zhi"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ebd.6400321"},{"key":"e_1_2_5_23_1","first-page":"213","article-title":"Tobacco smoking and oral clefts: a meta\u2010analysis","volume":"82","author":"Little J","year":"2004","journal-title":"Bull World Health Organ"},{"key":"e_1_2_5_24_1","first-page":"877","article-title":"Current tobacco use and secondhand smoke exposure among women of reproductive age \u2013 14 countries, 2008\u20132010","volume":"61","author":"Centers for Disease C, Prevention","year":"2012","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20285"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20177"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2009.01025.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn186"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2008.0065"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01810.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4614"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31824d0349"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12063"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.12311","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:11:34Z","timestamp":1696223494000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,31]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/jop.12311"],"URL":"https:\/\/doi.org\/10.1111\/jop.12311","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,31]]}}}