{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:37:11Z","timestamp":1788871031416,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T00:00:00Z","timestamp":1424995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["UBACyT 20020130100325BA"],"award-info":[{"award-number":["UBACyT 20020130100325BA"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 11220110100019"],"award-info":[{"award-number":["PIP 11220110100019"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,11]]},"abstract":"\n Background<\/jats:title>\n \n We demonstrate that serum immunoglobulin\n G<\/jats:styled-content>\n (\n I<\/jats:styled-content>\n g\n G<\/jats:styled-content>\n ) directed against glandular\n M<\/jats:styled-content>\n 3<\/jats:sub>\n muscarinic acetylcholine receptors (\n M<\/jats:styled-content>\n 3<\/jats:sub>\n m\n AC<\/jats:styled-content>\n h\n R<\/jats:styled-content>\n ) and pilocarpine triggers the increment of superoxide dismutase (\n SOD<\/jats:styled-content>\n ) and catalase (\n CAT<\/jats:styled-content>\n ) and the production of nitric oxide (\n NO<\/jats:styled-content>\n ) and prostaglandin\n E<\/jats:styled-content>\n 2<\/jats:sub>\n (\n PGE<\/jats:styled-content>\n 2<\/jats:sub>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Enzyme\u2010linked immunosorbent assay (\n ELISA<\/jats:styled-content>\n ) was performed in the presence of the human\n M<\/jats:styled-content>\n 3<\/jats:sub>\n m\n AC<\/jats:styled-content>\n h\n R<\/jats:styled-content>\n synthetic peptide as antigen to detect in serum of p\n SS<\/jats:styled-content>\n patients the autoantibodies. Further,\n SOD<\/jats:styled-content>\n and\n CAT<\/jats:styled-content>\n specific activity and\n NO<\/jats:styled-content>\n were determined chemically in the presence of anti\u2010\n M<\/jats:styled-content>\n 3<\/jats:sub>\n m\n AC<\/jats:styled-content>\n h\n R I<\/jats:styled-content>\n g\n G<\/jats:styled-content>\n and pilocarpine. The level of\n PGE<\/jats:styled-content>\n 2<\/jats:sub>\n generation in the presence of autoantibody and pilocarpine was determined by\n ELISA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n An association between anti\u2010\n M<\/jats:styled-content>\n 3<\/jats:sub>\n m\n AC<\/jats:styled-content>\n h\n R<\/jats:styled-content>\n autoantibodies and pilocarpine given the increment of the specific activity of\n SOD<\/jats:styled-content>\n and\n CAT<\/jats:styled-content>\n in the serum of p\n SS<\/jats:styled-content>\n patients and in the rat submandibular gland was observed. As a result of this action,\n M<\/jats:styled-content>\n 3<\/jats:sub>\n synthetic peptide and atropine abrogated the stimulatory action. The\n L<\/jats:styled-content>\n \u2010type calcium channel, calcium\/calmodulin complex and\n COX<\/jats:styled-content>\n \u20102 inhibitors selectively blocked the increment of the specific activity of\n SOD<\/jats:styled-content>\n and\n CAT<\/jats:styled-content>\n in the rat submandibular gland. An increased production of\n NO<\/jats:styled-content>\n and\n PGE<\/jats:styled-content>\n 2<\/jats:sub>\n by the cholinergic autoantibody and pilocarpine was also detected.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n On the basis of these results, the increment of the specific activity of\n SOD<\/jats:styled-content>\n and\n CAT<\/jats:styled-content>\n in p\n SS<\/jats:styled-content>\n patients as compared to control healthy individuals may be seen as a defensive reaction to the increment of the amount of\n ROS<\/jats:styled-content>\n , which becoming uncontrollable, leads to irreversible cellular and tissue damage.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.12313","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T08:34:34Z","timestamp":1425026074000},"page":"876-883","source":"Crossref","is-referenced-by-count":5,"title":["Action of anti\u2010\n M<\/scp>\n 3<\/sub>\n muscarinic acetylcholine receptor\n I<\/scp>\n g\n G<\/scp>\n of primary\n S<\/scp>\n j\u00f6gren's syndrome on the enzymatic antioxidant system in rat submandibular gland"],"prefix":"10.1111","volume":"44","author":[{"given":"Silvia","family":"Reina","sequence":"first","affiliation":[{"name":"Pharmacology Unit School of Dentistry University of Buenos Aires Buenos Aires Argentina"},{"name":"Argentina and National Research Council of Argentina (CONICET) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Pharmacology Unit School of Dentistry University of Buenos Aires Buenos Aires Argentina"},{"name":"Argentina and National Research Council of Argentina (CONICET) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Stranieri","sequence":"additional","affiliation":[{"name":"Pharmacology Unit School of Dentistry University of Buenos Aires Buenos Aires 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