{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T08:31:37Z","timestamp":1772008297794,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T00:00:00Z","timestamp":1426550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012150","name":"Shanghai Leading Academic Discipline Project","doi-asserted-by":"crossref","award":["S30206"],"award-info":[{"award-number":["S30206"]}],"id":[{"id":"10.13039\/501100012150","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81001206"],"award-info":[{"award-number":["81001206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Municipal Health Bureau Talent Cultivation Project","award":["XYQ2011029"],"award-info":[{"award-number":["XYQ2011029"]}]},{"name":"Science and Technology Commission of Shanghai","award":["08DZ2271100"],"award-info":[{"award-number":["08DZ2271100"]}]},{"name":"Program for Innovative Research Team of Shanghai Municipal Education Commission"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Many reports indicated LATS2 was a component of the Hippo pathway, could phosphorylate and inactivate YAP, acted as a tumor suppressor in human cancers. But few studies investigated the role of LATS2 in oral squamous cell carcinoma (OSCC) and clarified the mechanisms of regulation of LATS2 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The expressions of LATS2 and phosphorylated YAP were detected by Western blotting in HN6 cells treated with TNF\u2010\u03b1 in different time and different dose. Luciferase reporter assays were performed to detect whether YAP can be phosphorylated by LATS2 in HN6 cells. Cell proliferation, anchorage independent growth in soft agar, transwell cell invasion assay, and nu mice <jats:italic>in\u00a0vivo<\/jats:italic> xenografts growth were performed to study the effects of overexpression of LATS2 on OSCC cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, we confirmed that YAP can be phosphorylated by LATS2. LATS2 can be dose\u2010 and time\u2010dependently induced by TNF\u2010\u03b1 in HN6 cells. Overexpression of LATS2 inhibited cell proliferation, colony formation, cell invasion, and <jats:italic>in\u00a0vivo<\/jats:italic> xenografts growth in OSCC cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LATS2 could be induced by TNF\u2010alpha and inhibited cell proliferation and invasion by phosphorylating YAP in OSCC cells. LATS2 might play a role in the tumorigenesis of OSCC and might be a potential therapeutic target in OSCC treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12317","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T05:13:48Z","timestamp":1426655628000},"page":"475-481","source":"Crossref","is-referenced-by-count":22,"title":["<scp>LATS<\/scp>2 induced by <scp>TNF<\/scp>\u2010alpha and inhibited cell proliferation and invasion by phosphorylating <scp>YAP<\/scp> in oral squamous cell carcinoma"],"prefix":"10.1111","volume":"44","author":[{"given":"Cong","family":"Dong","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Stomatology Department of Oral and Cranio\u2010Maxillofacial Science Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Shanghai Stomatological Disease Center Shanghai 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