{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:43:55Z","timestamp":1785199435605,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81000446"],"award-info":[{"award-number":["81000446"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The important roles of<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2 and its receptor<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>2 had been reported in a series of inflammatory disorders. However, few studies investigated the potential role of<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2\/<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>2 axis in oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>). Therefore, this study aimed to detect the expression of<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2 and<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>2 in<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>lesions and compare their changes before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2 and<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>2 expression was investigated using immunohistochemical staining and real\u2010time<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>in 32 patients with<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>and eight controls. Moreover, changes in their expression after treatment with triamcinolone acetonide were assessed in lesions from three patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2+ and<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>2+ cells were few in the controls and remarkably increased in the epithelial and subepithelial layers of lesions (<jats:italic>n<\/jats:italic>\u00a0=\u00a032, all<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). However, the densities of<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2+ and<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>2+ cells were not significantly different between reticular (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) and erythematous\u2044erosive lesions (<jats:italic>n<\/jats:italic>\u00a0=\u00a020), although they significantly decreased after treatment (627.7\u00a0\u00b1\u00a0108.2 vs. 258.3\u00a0\u00b1\u00a0148.3,<jats:italic>P\u00a0<\/jats:italic>=\u00a00.017; 1034.7\u00a0\u00b1\u00a074.6 vs. 648\u00a0\u00b1\u00a077.6,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003, respectively).<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2+\/<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>2+ cell numbers were positively correlated with disease activity (correlation coefficient, 0.588;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; correlation coefficient, 0.409;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study indicated that the<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2\u2010<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>2 axis was involved in the pathogenesis of<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>and was positively correlated with disease activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12325","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T07:55:32Z","timestamp":1429516532000},"page":"41-47","source":"Crossref","is-referenced-by-count":7,"title":["The positive correlation of the<scp>CCL<\/scp>2\u2010<scp>CCR<\/scp>2 axis with the disease activity may indicate the fundamental role in the pathogenesis of oral lichen planus"],"prefix":"10.1111","volume":"45","author":[{"given":"Jingfang","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Periodontology Guangdong Provincial Stomatological Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linglan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoan","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Guanghua School of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.04.004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300405"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00946.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12090"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12094"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-013-0161-z"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0031-6997(24)01439-X","article-title":"International union of pharmacology. 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