{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:49:23Z","timestamp":1774442963459,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:00:00Z","timestamp":1433721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Council of Mashhad University of Medical Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) is an inflammatory disease with an unknown origin. Oxidative stress is suspected to play a role in its pathogenesis. The aim of this study was to evaluate serum levels of oxidative stress factors and C\u2010reactive protein in patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>In this case\u2013control study, 25 patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and 23 control subjects were enrolled. Serum levels of C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), malondialdehyde (<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>), and total antioxidant capacity (<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>) were investigated in both groups. In case group, all these factors were re\u2010evaluated after 14\u00a0days of treatment. The characteristics of the lesions were also recorded at each visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum levels of <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> were significantly higher (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.009), and <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> was significantly lower (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. There were no significant differences between serum levels of <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CRP<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> before and after treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.174, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.556, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.194, respectively). However, the difference in serum levels of <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> between erosive and atrophic patients with keratotic <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> was significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We concluded patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> have increased of serum <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> and the decrease of serum <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> compared with the healthy subjects, and 14\u2010day treatment of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> did not have any effect on serum levels of oxidative stress 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