{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:50:45Z","timestamp":1778827845792,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T00:00:00Z","timestamp":1432080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundation for Dental Research and Education","award":["Nr. 10-13\/26"],"award-info":[{"award-number":["Nr. 10-13\/26"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The distinction of oral lichenoid reactions from oral lichen planus may be difficult in a clinical setting. Our aims were to ascertain the utility of patch testing to confirm the association of oral lichenoid reactions with dental restorations and to identify the benefits of replacement of restorations, primarily made of amalgam.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients seen in an oral medicine unit over a 10\u2010year period diagnosed with oral lichenoid reactions, with oral lichen planus resistant to treatment or with atypical lichenoid features were included in this study. All had been subjected to skin patch testing. Histopathology reports blinded to patch test results were scrutinized. Patch\u2010test\u2010positive subjects were advised to have their restorations replaced. All were followed up to determine disease resolution for at least 3\u00a0months thereafter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 115 patients, 67.8% patients reacted positive to a dental material and nearly a quarter to mercury or amalgam. No correlation was found between pathology and skin patch testing results (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.44). A total of 87 patients were followed up in clinic, and among 26 patch\u2010test\u2010positive patients who had their amalgam fillings replaced, moderate to complete resolution was noted in 81%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Skin patch testing is a valuable tool to confirm clinically suspected oral lichenoid reactions. Pathology diagnoses of oral lichenoid reactions did not correlate with patch test results. Prospective studies are needed to ascertain that a clinically suspected oral lichenoid reaction with a positive patch test result may resolve after the replacement of amalgam fillings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12328","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T10:09:10Z","timestamp":1432116550000},"page":"48-57","source":"Crossref","is-referenced-by-count":52,"title":["The role of patch testing in the management of oral lichenoid reactions"],"prefix":"10.1111","volume":"45","author":[{"given":"Valerie G. 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