{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:11:55Z","timestamp":1791295915647,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T00:00:00Z","timestamp":1437782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Veterans General Hospital Kaohsiung, Taiwan","award":["VGHKS101-115"],"award-info":[{"award-number":["VGHKS101-115"]}]},{"name":"Veterans General Hospital Kaohsiung, Taiwan","award":["VGHKS102-002"],"award-info":[{"award-number":["VGHKS102-002"]}]},{"name":"Veterans General Hospital Kaohsiung, Taiwan","award":["VGHKS103-106"],"award-info":[{"award-number":["VGHKS103-106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,2]]},"abstract":"\n Background<\/jats:title>\n \n OCT<\/jats:styled-content>\n 4,\n SOX<\/jats:styled-content>\n 2, and\n NANOG<\/jats:styled-content>\n are major transcription factors related to stem cell self\u2010renewal and differentiation. The aim of this study was to examine the association of\n OCT<\/jats:styled-content>\n 4,\n SOX<\/jats:styled-content>\n 2, and\n NANOG<\/jats:styled-content>\n expression levels with the development and prognosis of patients with oral squamous cell carcinoma (\n OSCC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n Expression levels of\n OCT<\/jats:styled-content>\n 4,\n SOX<\/jats:styled-content>\n 2, and\n NANOG<\/jats:styled-content>\n were evaluated by immunohistochemistry with tissue microarray slides of 436\n OSCC<\/jats:styled-content>\n , 362 corresponding tumor\u2010adjacent normal (\n CTAN<\/jats:styled-content>\n ) tissues, and 71 normal uvula epithelium tissues. The clinicopathologic and follow\u2010up data of the\n OSCC<\/jats:styled-content>\n patients were recorded.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n OCT<\/jats:styled-content>\n 4 expression was significantly higher in normal and\n CTAN<\/jats:styled-content>\n tissues than in tumor tissue (both\n P\u00a0<\/jats:italic>\n <\u00a00.001).\n SOX<\/jats:styled-content>\n 2 expression in\n CTAN<\/jats:styled-content>\n tissue was significantly higher than that in normal (\n P<\/jats:italic>\n \u00a0=\u00a00.021) and tumor tissues (\n P<\/jats:italic>\n \u00a0<\u00a00.001). However,\n NANOG<\/jats:styled-content>\n expression was significantly higher in\n CTAN<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u00a0=\u00a00.014) and tumor tissues (\n P<\/jats:italic>\n \u00a0=\u00a00.009) than in normal tissue. Higher\n OCT<\/jats:styled-content>\n 4 and\n SOX<\/jats:styled-content>\n 2 expressions were associated with earlier\n AJCC<\/jats:styled-content>\n stage (\n P<\/jats:italic>\n \u00a0=\u00a00.002 and\n P<\/jats:italic>\n \u00a0<\u00a00.001), small tumor size (\n P<\/jats:italic>\n \u00a0=\u00a00.017 and\n P<\/jats:italic>\n \u00a0=\u00a00.001), and the absence of lymph node metastasis (\n P<\/jats:italic>\n \u00a0=\u00a00.015 and\n P<\/jats:italic>\n \u00a0=\u00a00.025). Higher levels of\n SOX<\/jats:styled-content>\n 2 expression were associated with better disease\u2010specific survival (\n P<\/jats:italic>\n \u00a0=\u00a00.002) even after adjustment for clinicopathologic factors.\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n \n OCT<\/jats:styled-content>\n 4 and\n SOX<\/jats:styled-content>\n 2 are biomarkers of tumorigenesis and early stage\n OSCC<\/jats:styled-content>\n .\n SOX<\/jats:styled-content>\n 2 is an independent prognostic factor for\n OSCC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.12335","type":"journal-article","created":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T02:17:10Z","timestamp":1437790630000},"page":"89-95","source":"Crossref","is-referenced-by-count":88,"title":["Association of\n OCT<\/scp>\n 4,\n SOX<\/scp>\n 2, and\n NANOG<\/scp>\n expression with oral squamous cell carcinoma progression"],"prefix":"10.1111","volume":"45","author":[{"given":"Ting\u2010Ying","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan"},{"name":"Shu\u2010Zen Junior College of Medicine and Mangement Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Chien","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiin\u2010Tsuey","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences National Sun Yat\u2010Sen University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Han","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Neurology Kaohsiung Chang Gung Memorial Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Yi","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Kaohsiung Veterans General Hospital Kaohsiung Taiwan"},{"name":"Department of Nursing Yuh\u2010Ing Junior College of Health Care and Management Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang\u2010Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huei\u2010Han","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung\u2010Chih","family":"Chen","sequence":"additional","affiliation":[{"name":"Shu\u2010Zen Junior College of Medicine and Mangement Kaohsiung Taiwan"},{"name":"Department of Stomatology Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leing\u2010Ming","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Hwa","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo\u2010Ping","family":"Ger","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences National Sun Yat\u2010Sen University Kaohsiung Taiwan"},{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2005.00251.x"},{"key":"e_1_2_5_3_1","unstructured":"Department of Health.Cancer Registry annual Report in Taiwan Area.Taipei:Department of Health 2008. 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