{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:46:39Z","timestamp":1760204799174},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T00:00:00Z","timestamp":1434499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200804","81470761"],"award-info":[{"award-number":["81200804","81470761"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010mobility group box protein\u20101 (<jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>\u20101), a potent promoter of inflammation, was believed to be a potential trigger of osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>). Only a few studies have investigated the role of <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>\u20101 in temporomandibular joint (<jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>, especially in disc perforation cases. But in this study, not only the expression of <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>\u20101 in <jats:styled-content style=\"fixed-case\">TMJ OA<\/jats:styled-content> with disc perforation was investigated but also the possible role of <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>\u20101 in <jats:styled-content style=\"fixed-case\">TMJ OA<\/jats:styled-content> was discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Synovial membrane and disc specimens were collected from patients with <jats:styled-content style=\"fixed-case\">TMJ OA<\/jats:styled-content>, and the expression of <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>\u20101 was detected using immunohistochemistry, real\u2010time quantitative <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and Western blotting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High\u2010mobility group box protein\u20101 expressed strongly in cytoplasm and nucleus of lining layer cells and endothelial cells in osteoarthritic synovium. Staining of <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>\u20101 was found intensive in the frontier tissue of the perforation in the perforated discs. <jats:styled-content style=\"fixed-case\">HMGB<\/jats:styled-content>\u20101 expression was also upregulated in osteoarthritic synovial cells and disc cells according to real\u2010time quantitative <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and Western blotting analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010mobility group box protein\u20101 expression was upregulated in <jats:styled-content style=\"fixed-case\">TMJ OA<\/jats:styled-content> and might promote the progression of <jats:styled-content style=\"fixed-case\">TMJ OA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12336","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T08:08:50Z","timestamp":1434528530000},"page":"148-152","source":"Crossref","is-referenced-by-count":10,"title":["The expression of high\u2010mobility group box protein\u20101 in temporomandibular joint osteoarthritis with disc perforation"],"prefix":"10.1111","volume":"45","author":[{"given":"Yaping","family":"Feng","sequence":"first","affiliation":[{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) &amp; 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