{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:12:17Z","timestamp":1786680737738,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Background<\/jats:title>Oral lichen planus (OLP<\/jats:styled-content>) is a chronic mucocutaneous disease, inflammatory and autoimmune in character, in which the pathogenesis is not fully understood. Psychological stress has also been implicated in triggering or exacerbating the disease.<\/jats:p><\/jats:sec>Objective<\/jats:title>The aim of this study was to evaluate the psychological profile, sleep, and salivary biological markers\u2014cortisol, immunoglobinA<\/jats:styled-content>(I<\/jats:styled-content>gA<\/jats:styled-content>), and adiponectin \u2013 in patients with oral lichen planus (OLP<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>The sample consisted of 65 patients (33 withOLP<\/jats:styled-content>and 32 control patients). Patients completed hospital anxiety and depression scales (HADD<\/jats:styled-content>,HADA<\/jats:styled-content>). Questionnaires were used to assess sleepiness: theP<\/jats:styled-content>ittsburgh sleep quality index (PSQI<\/jats:styled-content>) and theE<\/jats:styled-content>pworth sleepiness scale (ESS<\/jats:styled-content>). A visual analog scale (VAS<\/jats:styled-content>) was used for rating pain. Unstimulated whole saliva was evaluated, together with total proteins: cortisol,I<\/jats:styled-content>gA<\/jats:styled-content>, and adiponectin.<\/jats:p><\/jats:sec>Results<\/jats:title>Patients withOLP<\/jats:styled-content>obtained significantly higherHADA<\/jats:styled-content>andPSQI<\/jats:styled-content>scores than control subjects (P<\/jats:italic>\u00a0=\u00a00.001,P<\/jats:italic>\u00a0=\u00a00.012, respectively). Total salivary protein (flow at rest) analysis found that total proteins were higher in theOLP<\/jats:styled-content>group (P<\/jats:italic>\u00a0=\u00a00.001). In theOLP<\/jats:styled-content>group,I<\/jats:styled-content>gA<\/jats:styled-content>was 80.3\u00a0\u00b1\u00a051.3 vs. the control group 48.9\u00a0\u00b1\u00a032.8 (P<\/jats:italic>\u00a0=\u00a00.005). Mean cortisol was 0.5\u00a0\u00b1\u00a00.3\u00a0\u03bcg\/dl in theOLP<\/jats:styled-content>group vs. 0.4\u00a0\u00b1\u00a00.2\u00a0\u03bcg\/dl in the control group (P<\/jats:italic>\u00a0=\u00a00.010). TheOLP<\/jats:styled-content>group showed a correlation between theHADA<\/jats:styled-content>variable and pain (r<\/jats:italic>\u00a0=\u00a00.358;P<\/jats:italic>\u00a0=\u00a00.041),HADD<\/jats:styled-content>(r<\/jats:italic>\u00a0=\u00a00.568;P<\/jats:italic>\u00a0=\u00a00.001), andPSQI<\/jats:styled-content>(r<\/jats:italic>\u00a0=\u00a00.537;P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>OLP<\/jats:styled-content>patients presented worse psychological profiles and sleep disturbances, as well as higher values forI<\/jats:styled-content>gA<\/jats:styled-content>, cortisol, and total proteins than control subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12345","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T05:14:56Z","timestamp":1438060496000},"page":"211-217","source":"Crossref","is-referenced-by-count":52,"title":["Oral lichen planus: salival biomarkers cortisol, immunoglobulinA<\/scp>, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Escribano","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Regional Campus of International Excellence Mare Nostrum University of Murcia Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Ceron","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Regional Campus of International Excellence Mare Nostrum University of Murcia Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.07.199"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00946.x"},{"key":"e_1_2_5_4_1","first-page":"E310","article-title":"Oral lichen planus and oral lichenoid lesions; a critical appraisal with 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