{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T12:22:04Z","timestamp":1708431724449},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T00:00:00Z","timestamp":1440979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Objective<\/jats:title>There are few reports on the migration of CLA<\/jats:styled-content>+ T cells through E\u2010selectin in cutaneous lichen planus, with only one study on oral lichen planus (OLP<\/jats:styled-content>). This study aimed to analyze CLA<\/jats:styled-content> expression and assess whether there is a correlation with E\u2010selectin (CD<\/jats:styled-content>62E) in OLP<\/jats:styled-content> lesions.<\/jats:p><\/jats:sec>Material and methods<\/jats:title>Biopsies were performed on 11 patients including two areas: one without clinical and histopathological features of OLP<\/jats:styled-content> [perilesional group (PLG<\/jats:styled-content>)] and the other with clinical and histopathological features of OLP<\/jats:styled-content> [OLP<\/jats:styled-content> group (OLPG<\/jats:styled-content>)]. The specimens obtained were divided into two: One was fixed in formalin for routine analysis (H&E), and the other was frozen for CD<\/jats:styled-content>3, CD<\/jats:styled-content>4, CD<\/jats:styled-content>8, CLA<\/jats:styled-content>, and CD<\/jats:styled-content>62E immunofluorescence markers.<\/jats:p><\/jats:sec>Results<\/jats:title>More CD<\/jats:styled-content>4+ (median 1409, range 860\u20132519), CD<\/jats:styled-content>8+ (median 1568, range 654\u20133258), and CLA<\/jats:styled-content>+ T cells (median 958, range 453\u20132198) and higher CD<\/jats:styled-content>62E expression (median 37, range 27\u201385) were identified in OLPG<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.003; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.003; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.004; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.003, respectively) than those in PLG<\/jats:styled-content>. The median prevalence analysis was also significantly higher for CLA<\/jats:styled-content>+CD<\/jats:styled-content>8+ T cells in OLPG<\/jats:styled-content> (OLPG<\/jats:styled-content>\u00a0=\u00a039.4%, range 18.4\u201364.2; PLG<\/jats:styled-content>\u00a0=\u00a029.4%, range 12.1\u201347.1) (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.026). None of the correlations between CD<\/jats:styled-content>3+ or CLA<\/jats:styled-content>+ T cells and CD<\/jats:styled-content>62E in OLPG<\/jats:styled-content> and in PLG<\/jats:styled-content> were significant.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The significant presence of CLA<\/jats:styled-content>+ T cells and E\u2010selectin expressions in the OLPG<\/jats:styled-content> suggests their involvement in the etiopathogenesis of OLP<\/jats:styled-content>; however, only a weak correlation between CLA<\/jats:styled-content>+ T cells and E\u2010selectin was observed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12355","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T17:16:21Z","timestamp":1441214181000},"page":"218-223","source":"Crossref","is-referenced-by-count":2,"title":["CLA<\/scp> and CD<\/scp>62E expression in oral lichen planus lesions"],"prefix":"10.1111","volume":"45","author":[{"given":"Juliana 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