{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:18:54Z","timestamp":1787505534785,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The epithelial\u2013mesenchymal transition (\n                      <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>\n                      ) is the process where cells lose their epithelial features and acquire properties of typical mesenchymal cells. The dissociation of tumor cells due to changes in cell\u2013cell adhesion is one of the key principles of tumor invasion and\n                      <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>\n                      . Thus, the knowledge of the molecular features of\n                      <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>\n                      in keratocyst odontogenic tumor (\n                      <jats:styled-content style=\"fixed-case\">KOT<\/jats:styled-content>\n                      ) can provide useful markers to aid in the diagnosis and prognosis and perhaps contribute to an alternative therapeutic approach as it shows an aggressive clinical behavior and high recurrence rates. This study aimed to evaluate the\n                      <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>\n                      in\n                      <jats:styled-content style=\"fixed-case\">KOT<\/jats:styled-content>\n                      by the immunoexpression of E\u2010cadherin, N\u2010cadherin, Snail, and Slug and comparing to radicular cysts and dental follicles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010two\n                      <jats:styled-content style=\"fixed-case\">KOT<\/jats:styled-content>\n                      s, 15 radicular cysts, and 08 dental follicles were used for immunohistochemistry, evaluating the extent, intensity, labeling pattern, cellular compartment in the epithelium and stroma, and the presence of inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>E\u2010cadherin was preserved in most cases of keratocystic odontogenic tumor. N\u2010cadherin was increased in the tumor epithelium, a result that was positively correlated with the heterogeneous and nuclear immunoexpression of Slug in the epithelium; Slug also correlated with high Snail immunoexpression. N\u2010cadherin was positively correlated with Slug in the stroma of keratocystic odontogenic tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The high immunoexpression of Snail and nuclear Slug in keratocystic odontogenic tumors suggests these proteins as transcription factors without necessarily participating in \u2018cadherin switching\u2019. However, the knowledge of their induction of the epithelial\u2013mesenchymal transition in odontogenic tumors is still limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.12382","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T23:51:40Z","timestamp":1446508300000},"page":"302-311","source":"Crossref","is-referenced-by-count":11,"title":["E\u2010cadherin regulators are differentially expressed in the epithelium and stroma of keratocystic odontogenic tumors"],"prefix":"10.1111","volume":"45","author":[{"given":"Lia Pontes Arruda","family":"Porto","sequence":"first","affiliation":[{"name":"Pos\u2010graduate Program of Dentistry and Health School of Dentistry Federal University of Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Nunes","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Surgical Pathology Laboratory Department of Propaedeutics and Integrated Clinical 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