{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T11:04:26Z","timestamp":1759057466442},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T00:00:00Z","timestamp":1448496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cyclooxygenase\u20102 (COX\u20102) catalyses the conversion of arachidonic acid to prostaglandin, and its overexpression has been demonstrated in different malignant tumors, including cutaneous melanoma. However, no data about the expression of this protein in oral melanocytic lesions are available to date. The aim of this study was to evaluate the immunohistochemical expression of COX\u20102 in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>COX\u20102 was evaluated by immunohistochemistry in 49 oral melanocytic lesions, including 36 intramucosal nevi and 13 primary oral melanomas, and in four cutaneous nevi and eight melanomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All cases of oral and cutaneous melanomas were positive for COX\u20102. On the other hand, all oral and cutaneous melanocytic nevi were negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>COX\u20102 is highly positive in oral melanomas and negative in oral nevi and might represent a useful marker to distinguish melanocytic lesions of the oral cavity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12385","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T12:15:38Z","timestamp":1448540138000},"page":"440-443","source":"Crossref","is-referenced-by-count":13,"title":["Immunohistochemical expression of cyclooxygenase\u20102 (COX\u20102) in oral nevi and melanoma"],"prefix":"10.1111","volume":"45","author":[{"given":"Juliana","family":"de Souza do Nascimento","sequence":"first","affiliation":[{"name":"School of Dentistry Fluminense Federal University Nova Friburgo Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rom\u00e1n","family":"Carlos","sequence":"additional","affiliation":[{"name":"Pathology Section Centro Cl\u00ednico de Cabeza y Cuello\/Hospital Herrera Llerandi Guatemala City Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson","family":"Delgado\u2010Aza\u00f1ero","sequence":"additional","affiliation":[{"name":"Oral Pathology Universidad Peruana Cayetano Heredia Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adalberto","family":"Mosqueda Taylor","sequence":"additional","affiliation":[{"name":"Departamento de Atenci\u00f3n a la Salud Universidad Aut\u00f3noma Metropolitana Mexico Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oslei Paes","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Oral Pathology, School of Dentistry State University of Campinas Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio Jos\u00e9","family":"Roma\u00f1ach","sequence":"additional","affiliation":[{"name":"Oral Pathology, Department of Oral Diagnosis and Pathology, School of Dentistry Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Augusto Benevenuto","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Oral Pathology, Department of Oral Diagnosis and Pathology, School of Dentistry Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e3280dec6ac"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e32831d7f52"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04628.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2003.tb00222.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.2.6.627"},{"key":"e_1_2_5_7_1","first-page":"303","article-title":"Expression of cyclooxygenase 2 in human malignant melanoma","volume":"61","author":"Denkert C","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00939.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e32834defec"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cmr.0000194430.77643.a0"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.17588"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20201"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197011000-00017"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.375"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028006298.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1996.0113"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(00)00094-0"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.11.013"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2007.03.003"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200112000-00005"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01841.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1999"}],"container-title":["Journal of Oral Pathology &amp; 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