{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:24:06Z","timestamp":1790886246734,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate prolidase activity and oxidative stress in patients with oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) and oral lichenoid contact reactions (<jats:styled-content style=\"fixed-case\">OLCR<\/jats:styled-content>) using serum and salivary samples and to compare these biomarkers with each other as well as with a group of healthy subjects in order to be able to opine their role in the estimation of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OLCR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Eighteen recently diagnosed patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>, 32 patients with <jats:styled-content style=\"fixed-case\">OLCR<\/jats:styled-content> and 18 healthy controls with matched periodontal status were recruited to the study. Prolidase activity, lipid peroxidation product malondialdehyde (<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>), sialic acid (<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>), and advanced oxidation protein products (<jats:styled-content style=\"fixed-case\">AOPP<\/jats:styled-content>s) levels in both serum and saliva were determined. Additionally, salivary flow rate and its buffering capacity were estimated. Statistical analyses were performed using the chi\u2010square test, <jats:italic>t<\/jats:italic>\u2010test, Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test, and Spearman's rho correlation coefficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant differences were observed between the study groups and the control group regarding to the basic characteristics and the periodontal status (<jats:italic>P<\/jats:italic> &gt; 0.05). There were no statistically significant differences between <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OLCR<\/jats:styled-content> groups regarding to the distribution of lesions' type, severity, and location (<jats:italic>P<\/jats:italic> &gt; 0.05). No significant differences were found between the two study groups with regard to Prolidase activity, <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SA<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">AOPP<\/jats:styled-content>s (<jats:italic>P<\/jats:italic> \u02c3 0.05), whereas statistically significant differences were found between the two study groups and the control group with regard to all evaluated parameters except of serum prolidase (<jats:italic>P<\/jats:italic> \u02c2 0.01). Moderate correlation was found between salivary <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OLCR<\/jats:styled-content> lesion severity, whereas a weak correlation was observed between serum <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OLCR<\/jats:styled-content> lesion severity (<jats:italic>P<\/jats:italic> \u02c2 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of this study suggest an increased prolidase activity and oxidative stress and imbalance in the antioxidant defense system in biological fluids of patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OLCR<\/jats:styled-content> when compared with the healthy subjects. Both <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OLCR<\/jats:styled-content> patients revealed almost similar prolidase activity and oxidative stress levels although these two conditions have different etiopathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12391","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T12:52:56Z","timestamp":1450097576000},"page":"281-288","source":"Crossref","is-referenced-by-count":25,"title":["Evaluation of prolidase activity and oxidative stress in patients with oral lichen planus and oral lichenoid contact reactions"],"prefix":"10.1111","volume":"45","author":[{"given":"\u015eule","family":"Batu","sequence":"first","affiliation":[{"name":"Department of Biochemistry Faculty of Dentistry Istanbul University Istanbul 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