{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T01:16:59Z","timestamp":1725671819474},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the expression of activin receptor\u2010like kinase 1 (<jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>1) and investigate its possible relationship with microvessel density (<jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content>) in different forms of oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) compared to controls' biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Biopsies from 20 reticular\/papular <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> (R\/<jats:styled-content style=\"fixed-case\">PLP<\/jats:styled-content>), 20 atrophic\/erosive <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> (A\/<jats:styled-content style=\"fixed-case\">ELP<\/jats:styled-content>) patients, and 20 healthy subjects were immunohistochemically analyzed and statistically compared and correlated for <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>1 expression and <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content> as assessed by <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> specimens revealed the presence of positive cytoplasmic <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34 immunostaining in endothelial cells, with statistically high significant <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content> in each of R\/<jats:styled-content style=\"fixed-case\">PLP<\/jats:styled-content> (Median; <jats:italic>M<\/jats:italic> = 4.40) and A\/<jats:styled-content style=\"fixed-case\">ELP<\/jats:styled-content> (<jats:italic>M<\/jats:italic> = 7.69) compared to controls (<jats:italic>M<\/jats:italic> = 1.16) (<jats:italic>P<\/jats:italic> &lt; 0.001). Statistically significant <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content> was found in A\/<jats:styled-content style=\"fixed-case\">ELP<\/jats:styled-content> compared to R\/<jats:styled-content style=\"fixed-case\">PLP<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.001). All control specimens revealed negative <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>1 immunostaining of the few inflammatory cells found, while 85% of A\/<jats:styled-content style=\"fixed-case\">ELP<\/jats:styled-content> cases and 70% of R\/<jats:styled-content style=\"fixed-case\">PLP<\/jats:styled-content> cases showed positively immunostained sections for <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>\u20101, with statistically significant higher <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>1 expression In A\/<jats:styled-content style=\"fixed-case\">ELP<\/jats:styled-content> (<jats:italic>M<\/jats:italic> = 1.95) compared to R\/<jats:styled-content style=\"fixed-case\">PLP<\/jats:styled-content> (<jats:italic>M<\/jats:italic> = 0.86) (<jats:italic>P<\/jats:italic> = 0.005). No significant correlation between <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34 and <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>1 was detected in R\/<jats:styled-content style=\"fixed-case\">PLP<\/jats:styled-content> (<jats:italic>r<\/jats:italic> = 0.081), while a barely moderate positive correlation was found in A\/<jats:styled-content style=\"fixed-case\">ELP<\/jats:styled-content> (<jats:italic>r<\/jats:italic> = 0.396).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>1 expression and <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content> are increased in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>, particularly in A\/<jats:styled-content style=\"fixed-case\">ELP<\/jats:styled-content> type.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12396","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T12:18:21Z","timestamp":1450095501000},"page":"373-380","source":"Crossref","is-referenced-by-count":4,"title":["<scp>ALK<\/scp>1 expression in oral lichen planus: a possible relation to microvessel density"],"prefix":"10.1111","volume":"45","author":[{"given":"Hala H. A.","family":"Hazzaa","sequence":"first","affiliation":[{"name":"Oral Medicine, Diagnosis, Periodontology and Radiology Faculty of Dental Medicine Al Azhar University (Girls Branch) Cairo Egypt"},{"name":"Oral Medicine, Diagnosis, Periodontology and Radiology Faculty of Dentistry Nahda University Beni Swaif Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naglaa M.","family":"El\u2010Wakeel","sequence":"additional","affiliation":[{"name":"Oral Medicine, Diagnosis, Periodontology and Radiology Faculty of Dental Medicine Al Azhar University (Girls Branch) Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enas A. S.","family":"Attia","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Faculty of Medicine Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman A.","family":"Abo Hager","sequence":"additional","affiliation":[{"name":"Oral and Dental patholology Faculty of Dental Medicine Al Azhar University (Girls Branch) Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,14]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"62","article-title":"Oral Lichen Planus","volume":"2","author":"Shekar C","year":"2011","journal-title":"J Dent Sci Res"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0904-2512.2004.00064.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00134.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120452"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.92972"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)31102-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12012"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01441.x"},{"key":"e_1_2_6_10_1","volume-title":"Oral pathology; 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