{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:42:10Z","timestamp":1782402130416,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,1,17]],"date-time":"2016-01-17T00:00:00Z","timestamp":1452988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The immunogenic potential of dentin has been reported through dentin\u2010reactive autoantibodies detection in human and animal model. This study aimed to investigate the formation and diagnostic value of immune complexes formation after autoantibodies production, and soluble dentin antigens levels associated to root resorption, in the course of orthodontic tooth movement, in rat experimental model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty Wistar rats (<jats:italic>n<\/jats:italic> = 8 for each group) were submitted to orthodontic tooth movement, in which the maxillary right first molar was mesially moved by applying of 55 g of force for 3, 7, 14, or 21 days. Untreated group was used as control. Circulating autoantibodies to rat dentinal extract, immune complexes, and soluble dentinal antigen levels were determined by immunoenzyme assays. Additionally, dentinal antigens were analyzed by immunoblot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher serum dentin\u2010reactive IgG and immune complex levels were detected in the 14\u2010 and 21\u2010day groups (<jats:italic>p<\/jats:italic> &lt; 0.05 and <jats:italic>p<\/jats:italic> &lt; 0.001 respectively) but not in circulating dentinal antigen levels (<jats:italic>p<\/jats:italic> &gt; 0.05), as compared to the control group. Reactivity was found to dentinal components with molecular mass (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) ~120 and ~150 <jats:styled-content style=\"fixed-case\">kD<\/jats:styled-content>a, by immunoblot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This work represents the first evidence of immune complexes formation and circulating soluble dentin antigens associated to root resorption in orthodontic tooth movement. Immune complexes formation could be used to early diagnosis of external root resorption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12397","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T04:58:41Z","timestamp":1453093121000},"page":"546-550","source":"Crossref","is-referenced-by-count":1,"title":["Circulating dentinal antigen\u2010antibody immune complexes during orthodontic tooth movement in rats"],"prefix":"10.1111","volume":"45","author":[{"given":"T\u00e2nia Maris Pedrini Soares da","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Pathological Sciences State University of Londrina Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian Marubayashi","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Department of Dentistry State University of Maring\u00e1 Maring\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Consolaro","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Bauru School of Dentistry University of S\u00e3o Paulo Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo de Oliveira","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Dentistry Children's State University of Londrina Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelise Ono","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Dentistry Children's State University of Londrina Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Braga","family":"Trombeta","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences State University of Londrina Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiko Nakagawa","family":"Itano","sequence":"additional","affiliation":[{"name":"Department of Pathological Sciences State University of Londrina Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,17]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"175","article-title":"Orthodontically induced inflammatory root resorption. 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