{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:47:23Z","timestamp":1759693643287},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81170972","81371147"],"award-info":[{"award-number":["81170972","81371147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) is a chronic, T\u2010cell\u2010mediated inflammatory autoimmune disease. Human telomerase reverse transcriptase (<jats:styled-content style=\"fixed-case\">hTERT<\/jats:styled-content>), a catalytic subunit bearing the enzymatic activity of telomerase, may have a unique function in regulating the activation, proliferation, and function of T lymphocytes. The goal of this study was to investigate the expression of <jats:styled-content style=\"fixed-case\">hTERT<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells from patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and its correlation with clinical parameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The disease severity of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> was assessed by <jats:styled-content style=\"fixed-case\">RAE<\/jats:styled-content> (reticular, atrophic, erosive) scoring system. Expressions of <jats:styled-content style=\"fixed-case\">hTERT<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells isolated from peripheral blood of patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> were detected by real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, and their correlations with clinical features were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">hTERT mRNA<\/jats:styled-content> levels in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> were significantly lower than that of controls, while the levels in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells showed no statistical difference. The expression of <jats:styled-content style=\"fixed-case\">hTERT<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells was neither associated with disease severity nor gender. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> patients with the age \u226450 had markedly decreased <jats:styled-content style=\"fixed-case\">hTERT<\/jats:styled-content> levels compared with controls, but <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A divergent <jats:styled-content style=\"fixed-case\">hTERT<\/jats:styled-content> pattern between <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells was implicated in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. Decreased <jats:styled-content style=\"fixed-case\">hTERT<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells might be responsible for the immune dysfunction in OLP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12399","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T11:58:17Z","timestamp":1450094297000},"page":"516-522","source":"Crossref","is-referenced-by-count":7,"title":["Declined <scp>hTERT<\/scp> expression of peripheral blood <scp>CD<\/scp>4<sup>+<\/sup> T cells in oral lichen planus correlated with clinical parameter"],"prefix":"10.1111","volume":"45","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) &amp; Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral Medicine School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010hui","family":"Wei","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) &amp; Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Lu","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) &amp; Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral Medicine School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge\u2010fei","family":"Du","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) &amp; Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral Medicine School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zhou","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) &amp; Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral Medicine School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300405"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-64402004000100002"},{"key":"e_1_2_5_4_1","first-page":"1563","article-title":"Telomerase: structure, functions, and activity regulation","volume":"75","author":"Zvereva MI","year":"2010","journal-title":"Biochemistry"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2011.07.006"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00440-1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2007.11.005"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2018"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2002.5271"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt.10.107"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000268620"},{"key":"e_1_2_5_12_1","first-page":"524","article-title":"Telomere dysfunction, autoimmunity and aging","volume":"2","author":"Hohensinner PJ","year":"2011","journal-title":"Aging Dis"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.04.004"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04691.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-007-0472-9"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1998.tb01973.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.8.602"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9683-2"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.01.020"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206133"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2005.03.007"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.300"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.26329"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.03.031"},{"key":"e_1_2_5_25_1","first-page":"145","article-title":"The influence of psychological state on oral lichen planus","volume":"52","author":"Valter K","year":"2013","journal-title":"Acta Clin Croat"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.137946"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12148"},{"key":"e_1_2_5_28_1","first-page":"ZC01","article-title":"Association of salivary cortisol and anxiety levels in lichen planus patients","volume":"8","author":"Nadendla LK","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.12.004"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-178871"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02762.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2010.11.006"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000011"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.3.1191"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.12.002"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12399","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12399","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:28:37Z","timestamp":1696170517000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,14]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/jop.12399"],"URL":"https:\/\/doi.org\/10.1111\/jop.12399","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,14]]}}}