{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:44:12Z","timestamp":1792086252581,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Objective<\/jats:title>Little is known about the interaction of stromal components in odontogenic tumors. Thus, the aim of this study was to investigate mast cells (MC<\/jats:styled-content>s), myofibroblasts, macrophages, and their possible association with angiogenesis and lymphangiogenesis in keratocystic odontogenic tumors (KCOT<\/jats:styled-content>s).<\/jats:p><\/jats:sec>Material and Methods<\/jats:title>Thirty cases of KCOT<\/jats:styled-content>s were included and analyzed by immunohistochemistry for mast cell tryptase, \u03b1\u2010SMA<\/jats:styled-content>, CD<\/jats:styled-content>34, CD<\/jats:styled-content>163, and D240. For comparative purpose, 15 radicular cysts (CR<\/jats:styled-content>s) and 7 pericoronal follicles (PF<\/jats:styled-content>s) were included.<\/jats:p><\/jats:sec>Results<\/jats:title>There was an increase in MC<\/jats:styled-content>s for RC<\/jats:styled-content>s and this difference was significant when they were compared to KCOTS<\/jats:styled-content> and PF<\/jats:styled-content>s. A significant increase in the density of MF<\/jats:styled-content>s was observed for KCOT<\/jats:styled-content>s when compared to RC<\/jats:styled-content>s and PF<\/jats:styled-content>s (P<\/jats:italic> = 0.00). No significant difference in CD<\/jats:styled-content>163\u2010positive macrophages (P<\/jats:italic> = 0.084) and CD<\/jats:styled-content>34\u2010positive vessels (P<\/jats:italic> = 0.244) densities was observed between KCOT<\/jats:styled-content>s, RC<\/jats:styled-content>s, and PF<\/jats:styled-content>s, although KCOT<\/jats:styled-content>s showed a higher density of all proteins. Significant difference in lymphatic vessel density was observed for KCOT<\/jats:styled-content>s when compared to RC<\/jats:styled-content>s and PF<\/jats:styled-content>s (P<\/jats:italic> = 0.00). Positive correlation was observed between mast cell tryptase and CD<\/jats:styled-content>34 in KCOT<\/jats:styled-content>s (P<\/jats:italic> = 0.025).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>A significant interaction between the MC<\/jats:styled-content> population and CD<\/jats:styled-content>34\u2010positive vessels in KCOT<\/jats:styled-content>s supported the hypothesis that MC<\/jats:styled-content>s and blood vessels contribute to the stromal scaffold of KCOT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12400","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T14:28:55Z","timestamp":1452608935000},"page":"557-564","source":"Crossref","is-referenced-by-count":9,"title":["Interaction of stromal and microvascular components in keratocystic odontogenic tumors"],"prefix":"10.1111","volume":"45","author":[{"given":"Ernesto Santos","family":"Sousa\u2010Neto","sequence":"first","affiliation":[{"name":"Dentistry and Health Postgraduate Program School of Dentistry Federal University of Bahia Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina Teixeira","family":"Cangussu","sequence":"additional","affiliation":[{"name":"Dentistry and Health Postgraduate Program School of Dentistry Federal University of Bahia Salvador Bahia Brazil"},{"name":"Department of Dental Public Health School of Dentistry Federal University of Bahia Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-2985","authenticated-orcid":false,"given":"Clarissa Ara\u00fajo","family":"Gurgel","sequence":"additional","affiliation":[{"name":"Dentistry and Health Postgraduate Program School of Dentistry Federal University of Bahia Salvador Bahia Brazil"},{"name":"Human Pathology Postgraduate Program Oswaldo Cruz Foundation, Fiocruz Salvador Bahia Brazil"},{"name":"Laboratory of Pathology and Molecular Biology Oswaldo Cruz Foundation, Fiocruz Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Sousa","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology and Molecular Biology Oswaldo Cruz Foundation, Fiocruz Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Ant\u00f4nio Gon\u00e7alves","family":"Ramos","sequence":"additional","affiliation":[{"name":"Human Pathology Postgraduate Program Oswaldo Cruz Foundation, Fiocruz Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Cal\u00f3 Aquino","family":"Xavier","sequence":"additional","affiliation":[{"name":"Dentistry and Health Postgraduate Program School of Dentistry Federal University of Bahia Salvador Bahia Brazil"},{"name":"Laboratory of Oral Surgical Pathology School of Dentistry Federal University of Bahia Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Ramos","family":"Cury","sequence":"additional","affiliation":[{"name":"Dentistry and Health Postgraduate Program School of Dentistry Federal University of Bahia Salvador Bahia Brazil"},{"name":"Division of Periodontics School of Dentistry Federal University of Bahia Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bra\u00falio","family":"Carneiro J\u00fanior","sequence":"additional","affiliation":[{"name":"Dentistry and Health Postgraduate Program School of Dentistry Federal University of Bahia Salvador Bahia Brazil"},{"name":"Department of Oral and Maxillofacial Surgery School of Dentistry Federal University of Bahia Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalia","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Nunes","family":"Dos Santos","sequence":"additional","affiliation":[{"name":"Dentistry and Health Postgraduate Program School of Dentistry Federal University of Bahia Salvador Bahia Brazil"},{"name":"Human Pathology Postgraduate Program Oswaldo Cruz Foundation, Fiocruz Salvador Bahia Brazil"},{"name":"Laboratory of Oral Surgical Pathology School of Dentistry Federal University of Bahia Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,12]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"306","volume-title":"Barnes L. 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