{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T02:52:27Z","timestamp":1775703147199,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200804"],"award-info":[{"award-number":["81200804"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470761"],"award-info":[{"award-number":["81470761"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401241"],"award-info":[{"award-number":["81401241"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Background<\/jats:title>Temporomandibular joint (TMJ<\/jats:styled-content>) osteoarthritis(OA<\/jats:styled-content>)characterized with cartilage degen\u2010eration is associated with inflammation. High mobility group box chromosomal protein\u20101(HMGB<\/jats:styled-content>\u20101)is a potent mediator of inflammation and the trigger of OA<\/jats:styled-content>. The expression of HMGB<\/jats:styled-content>\u20101 in TMJ OA<\/jats:styled-content> was uncovered, but the role of HMGB<\/jats:styled-content>\u20101 in TMJ<\/jats:styled-content> cartilage degeneration is not fully understood. In this study, the regulation of HMGB<\/jats:styled-content>\u20101 in TMJ<\/jats:styled-content> condylar cartilage was revealed.<\/jats:p><\/jats:sec>Methods<\/jats:title>A complete Freund's adjuvant (CFA<\/jats:styled-content>)\u2010induced TMJ<\/jats:styled-content> inflammation animal model was employed and the expression of HMGB<\/jats:styled-content>\u20101 was detected at 1st, 2nd, and 6th weeks by immunohistochemistry. TMJ<\/jats:styled-content> condylar chondrocytes were incubated with IL<\/jats:styled-content>\u20101\u03b2 (10 and 40 ng\/ml) at 24, 48, and 72 h, and the translocation and protein level of HMGB<\/jats:styled-content>\u20101 were evaluated by immunofluorescence and Western blot.<\/jats:p><\/jats:sec>Result<\/jats:title>Nuclear HMGB<\/jats:styled-content>\u20101 staining was predominantly located in chondrocytes of both the fibrosis and proliferative zones in healthy TMJ<\/jats:styled-content>. 1st week and 2nd week after CFA<\/jats:styled-content> injection, immunoreaction could be detected in the cytoplasms of HMGB<\/jats:styled-content>\u20101\u2010positive cells and cartilage matrix especially in hypertrophic zone. At 6th week after CFA<\/jats:styled-content> injection, cartilage matrix expression was disappeared and the cytoplasm expression of HMGB<\/jats:styled-content>\u20101 was very weak in hypertrophic zone. HMGB<\/jats:styled-content>\u20101 was translocated from the nucleus to the cytoplasm at 48 h after incubated with IL<\/jats:styled-content>\u20101\u03b2 (10 ng\/ml and 40 ng\/ml). The protein level of HMGB<\/jats:styled-content>\u20101 was increased after stimulation and had a peak at 48 h.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>HMGB<\/jats:styled-content>\u20101 might be associated with TMJ<\/jats:styled-content> inflammation and OA<\/jats:styled-content>. Insight into the role of HMGB<\/jats:styled-content>\u20101 in TMJ<\/jats:styled-content> inflammation is helpful to add the new knowledge into the pathogenesis of TMJ OA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12401","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T12:21:38Z","timestamp":1450268498000},"page":"539-545","source":"Crossref","is-referenced-by-count":15,"title":["IL<\/scp>\u20101\u03b2 mediating high mobility group box protein\u20101 expression in condylar chondrocyte during temporomandibular joint inflammation"],"prefix":"10.1111","volume":"45","author":[{"given":"Cheng","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) & Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM) School and Hospital of Stomatology Wuhan University Wuhan 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