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In subepithelial and lamina propria of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> local lesions, the presence of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T helper (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> Th) cells appeared as the major lymphocytes. These <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T lymphocytes can differentiate into distinct Th cell types such as Th1, Th2, Treg, Th17, Th22, Th9, and Tfh within the context of certain cytokines environment. Growing evidence indicated that Th1\/Th2 imbalance may greatly participate into the cytokine network of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> immunopathology. In addition, Th1\/Th2 imbalance can be regulated by the Treg subset and also greatly influenced by the emerging novel <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> Th subset Th17. Furthermore, the presence of novel subsets Th22, Th9 and Tfh in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> patients is yet to be clarified. All these Th subsets and their specific cytokines may play a critical role in determining the character, extent and duration of immune responses in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> pathogenesis. Therefore, we review the roles of distinct <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> Th subsets and their signature cytokines in determining disease severity and susceptibility of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and also reveal the novel therapeutic strategies based on T lymphocytes subsets in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> treatment.<\/jats:p>","DOI":"10.1111\/jop.12405","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T07:40:44Z","timestamp":1450856444000},"page":"385-393","source":"Crossref","is-referenced-by-count":89,"title":["Role of distinct <scp>CD<\/scp>4<sup>+<\/sup><scp>T<\/scp> helper subset in pathogenesis of oral lichen planus"],"prefix":"10.1111","volume":"45","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oral Medicine School of Stomatology Capital Medical 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