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This investigation was carried out to furnish ultrastructural evidences for melatonin transport by salivary gland cells in order to indicate plausible routes by which circulating melatonin can reach saliva.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bioptic samples of parotid, submandibular and labial glands were processed for the electron microscopy and treated to demonstrate melatonin reactivity by the immunogold staining method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusions<\/jats:title><jats:p>The preferential sites of melatonin reactivity were the granules and vesicles of serous cells. Our results suggested that the acinar cells are able to store melatonin and that the hormone can be released into saliva through granule and vesicle exocytosis. The quantitative evaluation of labelling showed that the parotid gland is the most involved in the release of melatonin in saliva.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12409","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T07:40:44Z","timestamp":1450856444000},"page":"510-515","source":"Crossref","is-referenced-by-count":15,"title":["Melatonin localization in human salivary glands"],"prefix":"10.1111","volume":"45","author":[{"given":"Michela","family":"Isola","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari Monserrato Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Alberta","family":"Lilliu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari Monserrato Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.08.025"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.12.004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1579-2"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(85)90412-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-010-1278-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/720185"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1659-3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2008.00581.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12210"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2011.00931.x"},{"key":"e_1_2_5_12_1","first-page":"5","article-title":"Melatonin and its role in oxidative stress related diseases of oral cavity","volume":"58","author":"Czesnikiewicz\u2010Guzik M","year":"2007","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060396"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01610.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/491872"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1987.tb01172.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/074873049701200507"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1990.tb00692.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-011-0800-8"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12105"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12176"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0869-0_4"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070260105"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411970080010301"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000313703"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01725.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01824.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01884.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12238"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23255"},{"key":"e_1_2_5_31_1","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1242\/jcs.109.10.2591","article-title":"Two regulated secretory pathways for newly synthesized parotid salivary proteins are distinguished by doses of secretagogues","volume":"109","author":"Castle JD","year":"1996","journal-title":"J Cell Sci"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090010301"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100211200"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:27:2:101"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2008.00609.x"},{"key":"e_1_2_5_36_1","first-page":"4765","article-title":"MTNR1A receptor expression in normal and pathological human salivary glands","volume":"32","author":"Arias\u2010Santiago S","year":"2012","journal-title":"Anticancer Res"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-012-9575-z"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1108"}],"container-title":["Journal of Oral Pathology &amp; 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