{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:28:52Z","timestamp":1789972132588,"version":"4.0.1"},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T00:00:00Z","timestamp":1452470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Management of medication\u2010related osteone\u2010crosis of the jaw (<jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content>) with active infection can be a serious challenge for clinicians. Based on Association of Oral and Maxillofacial Surgeons (<jats:styled-content style=\"fixed-case\">AAOMS<\/jats:styled-content>) recommendations, we have tested a modified treatment protocol using topical minocycline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Five patients diagnosed with stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">III MRONJ<\/jats:styled-content> lesions were willing to consent to our protocol. In addition to conventional treatment as suggested by the <jats:styled-content style=\"fixed-case\">AAOMS<\/jats:styled-content>, such as, surgical debridement, chlorhexidine irrigation, and systemic antibiotics, we applied 10% minocycline to the lesions once a week for sustained local antibiotic delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All five patients reported pain relief after the first minocycline application. Complete healing occurred in three patients; case three healed completely after the third application, one case continues to improve toward resolution and one withdraws due to other non\u2010relevant medical problem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, we are reporting favorable results using a modified protocol with topical minocycline to treat <jats:styled-content style=\"fixed-case\">MRONJ<\/jats:styled-content> lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12419","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T05:45:23Z","timestamp":1452491123000},"page":"718-720","source":"Crossref","is-referenced-by-count":12,"title":["Modified protocol including topical minocycline in orabase to manage medication\u2010related osteonecrosis of the jaw cases"],"prefix":"10.1111","volume":"45","author":[{"given":"Jumana A.","family":"Karasneh","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Orofacial Pain Division of Diagnostic Sciences University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Al\u2010Eryani","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Orofacial Pain Division of Diagnostic Sciences University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn T.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Orofacial Pain Division of Diagnostic Sciences University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parish P.","family":"Sedghizadeh","sequence":"additional","affiliation":[{"name":"Centre for Biofilms University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199603)30:3<281::AID-JBM2>3.0.CO;2-M"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.08.007"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3629258"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000143571.18892.8d"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720110793566290"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.03.018"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12139"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200303000-00002"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.10.005"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12419","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:27:31Z","timestamp":1695497251000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,11]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/jop.12419"],"URL":"https:\/\/doi.org\/10.1111\/jop.12419","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,11]]}}}