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Based upon its central importance in oral carcinogenesis, the finding that the PI3k\/Akt\/mTOR pathway is activated in oral lichen planus, chronic graft\u2010versus\u2010host disease, and chronic oral candidiasis suggests that it may provide a link between benign and malignant oral conditions. Here, we discuss a possible mechanistic rationale that addresses the activation of this important signaling pathway and its downstream events, while correlating it with the carcinogenic potential of chronic oral disorders.<\/jats:p>","DOI":"10.1111\/jop.12436","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T00:53:17Z","timestamp":1458348797000},"page":"469-474","source":"Crossref","is-referenced-by-count":13,"title":["Could the PI3K canonical pathway be a common link between chronic inflammatory conditions and oral carcinogenesis?"],"prefix":"10.1111","volume":"45","author":[{"given":"Stephen T.","family":"Sonis","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital and the Dana\u2010Farber Cancer Institute and Biomodels LLC Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7628-8598","authenticated-orcid":false,"given":"Rui","family":"Amaral 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