{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:39Z","timestamp":1787015619295,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T00:00:00Z","timestamp":1458691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7142168"],"award-info":[{"award-number":["7142168"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pemphigus is one of the potentially fatal autoimmune blistering diseases. An early and accurate diagnosis is important for prognosis and therapy. It may be difficult to diagnosis based on clinical grounds alone. Direct and indirect immunofluorescence, enzyme\u2010linked immunosorbent assay, the Tzanck smear test, or histopathology are all available for the diagnosis of pemphigus. However, there are no generally accepted diagnostic criteria for the diagnosis of this condition at present.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the diagnostic value of indirect immunofluorescence, enzyme\u2010linked immunosorbent assay, and the Tzanck smear test for the diagnosis of pemphigus in dental clinics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010center retrospective study was conducted, and the clinical data of 33 patients with pemphigus and 61 controls were collected and analyzed from the Department of Oral Medicine, Peking University School of Stomatology, during 2010\u20132014. The sensitivities and specificities of indirect immunofluorescence, enzyme\u2010linked immunosorbent assay, and the Tzanck smear test were calculated and compared in two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sensitivities for the Tzanck smear test, indirect immunofluorescence, and enzyme\u2010linked immunosorbent assay were 96.7%, 84.8%, and 84.8%, respectively, whereas the specificities of these tests were 60%, 91.8%, and 96.7%, respectively. The serial tests for the Tzanck smear test and enzyme\u2010linked immunosorbent assay showed 82% sensitivity and 98.7% specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The serial test for the Tzanck smear test and enzyme\u2010linked immunosorbent assay may represent a simple, rapid, and reliable way to definitive diagnosis of pemphigus. It is recommended as a common test for the diagnosis of pemphigus in dental clinics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.12439","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T08:55:28Z","timestamp":1458723328000},"page":"786-790","source":"Crossref","is-referenced-by-count":14,"title":["Comparative study of indirect immunofluorescence, enzyme\u2010linked immunosorbent assay, and the Tzanck smear test for the diagnosis of pemphigus"],"prefix":"10.1111","volume":"45","author":[{"given":"Tingting","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyue","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.04.039"},{"issue":"1","key":"e_1_2_5_3_1","first-page":"CD006263","article-title":"Interventions for pemphigus vulgaris and pemphigus foliaceus","author":"Martin LK","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0278-x"},{"key":"e_1_2_5_5_1","first-page":"502","article-title":"Epidemiological research status abroad on pemphigus","volume":"123","author":"Xu HH","year":"2007","journal-title":"J Clin Stomatol"},{"key":"e_1_2_5_6_1","first-page":"81","article-title":"Developments in diagnosis and treatment of pemphigus","volume":"24","author":"Hua H","year":"2010","journal-title":"J Modern Stomatol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66829-8"},{"key":"e_1_2_5_8_1","first-page":"736","article-title":"The significance of direct immunofluorescence test in the diagnosis of oral mucosal bullous diseases","volume":"7","author":"Li YJ","year":"2014","journal-title":"Chin J Practical Stomatol"},{"key":"e_1_2_5_9_1","first-page":"115","article-title":"Advances on diagnosis and therapeutics of Pemphigus Vulgaris and Pemphigus Foliaceus","volume":"22","author":"Hou CJ","year":"2008","journal-title":"Chin J Derm Venereol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02541.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04294.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04428.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.059"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-002-0367-2"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.011"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02752.x"},{"key":"e_1_2_5_17_1","first-page":"1663","article-title":"Evaluation of sensitivity and specificity of enzyme\u2010linked immunosorbent assay (ELISA) for detecting antidesmoglein 1 and 3 in Thai patients with pemphigus vulgaris and foliaceus","volume":"91","author":"Kulkollakarn S","year":"2008","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051774"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2340\/0001555566127133","article-title":"Diagnostic value of Tzanck smear in herpetic and non\u2010herpetic vesicular and bullous skin disorders in paediatric practice","volume":"66","author":"Oranje AP","year":"1986","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.16632"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.169729"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05665.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890260105016"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12439","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12439","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T16:00:34Z","timestamp":1696262434000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,23]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/jop.12439"],"URL":"https:\/\/doi.org\/10.1111\/jop.12439","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,23]]}}}