{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T02:05:01Z","timestamp":1768788301804,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Geographic tongue (GT) is a benign inflammatory condition usually involving the dorsal surface and lateral borders of the tongue. Numerous etiological factors of GT have been suggested, including immunological factors; genetic; atopic or allergic predisposition; emotional stress; and hormonal disturbances. GT may also coexist as one of the possible manifestations of celiac disease (CD). Therefore, the aim of this study was to investigate the prevalence of CD, positive serologic tests for CD screening, and HLA\u2010DQ presence in patients with GT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tissue transglutaminase antibodies (anti\u2010tTG), antibodies against gliadin (AGA), and human leukocyte antigen (HLA) typing were assessed for 60 GT patients and 60 healthy control subjects. The duodenal biopsy was performed in patients with positive serologic tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 9 (15%) GT patients were positive for IgA tTG, and in those patients histological changes consistent with CD were confirmed by duodenal biopsy. Only two of them reported the presence of gastrointestinal symptoms. There were statistically significant differences between the GT patients and control group for immunoglobulin (Ig) A tTG (<jats:italic>P<\/jats:italic> = 0.03), IgG tTG (<jats:italic>P<\/jats:italic> = 0.04), IgA AGA (<jats:italic>P<\/jats:italic> = 0.04), and IgG AGA (<jats:italic>P<\/jats:italic> = 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of our study demonstrated the increased prevalence of CD in patients with GT. Therefore, the clinical oral examination should be considered a diagnostic tool, especially in atypical or silent forms of CD, since it may contribute to provide an early diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12450","type":"journal-article","created":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T20:29:43Z","timestamp":1462134583000},"page":"791-796","source":"Crossref","is-referenced-by-count":22,"title":["The prevalence of celiac disease in patients with geographic tongue"],"prefix":"10.1111","volume":"45","author":[{"given":"Livia","family":"Cigic","sequence":"first","affiliation":[{"name":"Study of Dental Medicine School of Medicine University of Split Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tea","family":"Galic","sequence":"additional","affiliation":[{"name":"Study of Dental Medicine School of Medicine University of Split Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darko","family":"Kero","sequence":"additional","affiliation":[{"name":"Study of Dental Medicine School of Medicine University of Split Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Simunic","sequence":"additional","affiliation":[{"name":"School of Medicine University of Split Split Croatia"},{"name":"Clinical Department of Internal Medicine University Clinic of Split Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Medvedec Mikic","sequence":"additional","affiliation":[{"name":"Study of Dental Medicine School of Medicine University of Split Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danijela","family":"Kalibovic Govorko","sequence":"additional","affiliation":[{"name":"Study of Dental Medicine School of Medicine University of Split Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Biocina Lukenda","sequence":"additional","affiliation":[{"name":"Study of Dental Medicine School of Medicine University of Split Split Croatia"},{"name":"Dental clinic Split Split Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00559.x"},{"key":"e_1_2_5_3_1","first-page":"103","volume-title":"Burkets Oral Medicine","author":"Greenbreg M","year":"2008"},{"key":"e_1_2_5_4_1","first-page":"83","article-title":"Frequency, clinical characteristics and factors associated with geographic tongue","volume":"9","author":"Hashemipour M","year":"2008","journal-title":"Shiraz J Dent"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01208.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.127581"},{"key":"e_1_2_5_7_1","first-page":"42","article-title":"Oral manifestations of celiac disease: a clinical guide for dentists","volume":"93","author":"Rashid M","year":"2011","journal-title":"J Mich Dent Assoc"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i42.6036"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.22123"},{"key":"e_1_2_5_11_1","first-page":"2259","article-title":"Gluten\u2010sensitive enteropathy (celiac disease): more common than you think","volume":"66","author":"Nelsen DA","year":"2002","journal-title":"Am Fam Physician"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldn044"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05471.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc070200"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/MCG.0b013e318074dd98","article-title":"Oral manifestations of coeliac disease","volume":"42","author":"Pastore L","year":"2008","journal-title":"J Clin Gastroenterol"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/37212"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181ac9942"},{"key":"e_1_2_5_18_1","first-page":"136","article-title":"Dental enamel defects in children with coeliac disease","volume":"17","author":"Wiernik CD","year":"2007","journal-title":"Int J Paediatr Dent"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6000.11"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90989-X"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1288-0"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.09.66"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.64"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.276"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830185.2011.602443"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000247995.12087.7b"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14259.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1995.tb01128.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-031104"},{"key":"e_1_2_5_30_1","first-page":"309","article-title":"Oral manifestations of systemic diseases","volume":"65","author":"Long RG","year":"1998","journal-title":"Mt Sinai J Med"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12450","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T19:59:43Z","timestamp":1696276783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/jop.12450"],"URL":"https:\/\/doi.org\/10.1111\/jop.12450","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]}}}