{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:23:25Z","timestamp":1768285405243,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T00:00:00Z","timestamp":1464566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Early detection of oral cancer has been the most effective approach to reduce morbidity and mortality of cancer patients. If a lesion is clinically considered suspicious, an easily practicable, non\u2010invasive, painless, safe, and accurate screening method for detection of the dysplastic changes is necessary. In an attempt to procure this, a study was conducted with the aim of determining the diagnostic accuracy of rapid Papanicolaou stain (<jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content>) and silver\u2010stained nucleolar organizer regions (Ag<jats:styled-content style=\"fixed-case\">NOR<\/jats:styled-content>) in brush biopsies of potentially malignant lesions for early detection of oral cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Brush biopsies taken from 25 cases of leukoplakia and lichen planus each were stained with rapid <jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content> and silver nitrate stains. Histopathological correlation was performed and further compared with rapid <jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content> and Ag<jats:styled-content style=\"fixed-case\">NOR<\/jats:styled-content> for its diagnostic validity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant increase in the mean Ag<jats:styled-content style=\"fixed-case\">NOR<\/jats:styled-content> count was seen from normal epithelium to lichen planus to that of leukoplakia. When compared with rapid <jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content>, a linear correlation was seen in Ag<jats:styled-content style=\"fixed-case\">NOR<\/jats:styled-content> counts and stages of dysplasia in leukoplakia which was also found to be statistically significant. Diagnostic accuracy for Ag<jats:styled-content style=\"fixed-case\">NOR<\/jats:styled-content> in leukoplakia was found to be 84%, lichen planus 73%, whereas <jats:styled-content style=\"fixed-case\">RAPID PAP<\/jats:styled-content> showed 72% accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ag<jats:styled-content style=\"fixed-case\">NOR<\/jats:styled-content> analysis may be useful as a quantitative marker of incipient cellular alterations and hence would be helpful in assessing suspicious lesions and thus can be regarded as a valuable adjunct.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12457","type":"journal-article","created":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T10:46:45Z","timestamp":1464605205000},"page":"56-60","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of diagnostic value of Ag<scp>NOR<\/scp> and <scp>PAP<\/scp> in early detection of dysplastic changes in leukoplakia and lichen planus \u2013 a preliminary case\u2013control study"],"prefix":"10.1111","volume":"46","author":[{"given":"Dhanya S.","family":"Rao","sequence":"first","affiliation":[{"name":"Oral Medicine and Radiology A J institute of Dental Sciences Mangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. M.","family":"Ali","sequence":"additional","affiliation":[{"name":"Oral Medicine and Radiology College of Dental Sciences Davangere Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeshwari G.","family":"Annigeri","sequence":"additional","affiliation":[{"name":"Oral Medicine and Radiology College of Dental Sciences Davangere Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(97)00002-X"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdip.2005.10.008"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00102-7"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-6053(05)80014-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.016"},{"key":"e_1_2_5_7_1","volume-title":"Cytopathology","author":"Naib ZM","year":"1996"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2008.02.030"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2011.514"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1992.tb01010.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(05)80060-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711550203"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90015-2"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711580303"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.72501"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970601)79:11<2200::AID-CNCR19>3.0.CO;2-#"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2013.002"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2002.00153.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.2.e173"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.14.e563"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2001.00747.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.01000.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.21726\/rsbo.v8i3.1067","article-title":"Accuracy of oral exfoliative cytology in Sudanese patients undergoing oral biopsy","volume":"8","author":"Edris M","year":"2011","journal-title":"RSBO"},{"key":"e_1_2_5_24_1","first-page":"436","article-title":"An investigation of the use of exfoliative cytology in the diagnosis of malignant lesions of the oral cavity","volume":"8","author":"Gardner AF","year":"1964","journal-title":"Acta Cytol"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12457","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T06:03:51Z","timestamp":1695708231000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,30]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/jop.12457"],"URL":"https:\/\/doi.org\/10.1111\/jop.12457","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,30]]}}}