{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:24:10Z","timestamp":1782487450685,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T00:00:00Z","timestamp":1466121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oral submucous fibrosis is a chronic disease, treatment of which has largely been symptomatic. Aloe vera has immunomodulatory, anti\u2010inflammatory, wound healing, antioxidant, and antineoplastic activities. All such properties of aloe vera suggest the possibility of its use in the management of oral submucous fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010four patients of oral submucous fibrosis were randomly divided into 2 groups. Group A patients were treated with systemic (juice) and topical aloe vera (gel) for 3 months. Group B patients were treated with intralesional injection of hydrocortisone and hyaluronidase for 6 weeks with antioxidant supplements for 3 months. Patients were assessed for reduction in burning sensation and increase in mouth opening, cheek flexibility, and tongue protrusion at an interval of 1, 2, and 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the groups showed statistically significant improvements in all the study parameters at the end of study period (<jats:italic>P<\/jats:italic> &lt; 0.001). The clinical response to aloe vera was comparable to that of intralesional injections of hydrocortisone and hyaluronidase with antioxidant supplementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study concludes that aloe vera can be an alternative, safe, and effective treatment regime in the management of oral submucous fibrosis. Long\u2010term follow\u2010up studies with larger sample size are recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12463","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T13:56:55Z","timestamp":1466171815000},"page":"50-55","source":"Crossref","is-referenced-by-count":55,"title":["Evaluation of efficacy of aloe vera in the treatment of oral submucous fibrosis \u2013 a clinical study"],"prefix":"10.1111","volume":"46","author":[{"given":"Ardra","family":"Anuradha","sequence":"first","affiliation":[{"name":"Department of Oral medicine &amp; radiology The Oxford College and Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharati","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Oral medicine &amp; radiology The Oxford College and Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkataswamy Reddy","family":"Asha","sequence":"additional","affiliation":[{"name":"Department of Oral medicine &amp; radiology The Oxford College and Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,17]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"985","article-title":"Oral submucous fibrosis: etiology, pathogenesis, and future research","volume":"72","author":"Rajendran R","year":"1994","journal-title":"Bull World Health Organ"},{"key":"e_1_2_8_3_1","first-page":"147","article-title":"Medical Treatment Modalities of Oral Sub Mucous Fibrosis","volume":"3","author":"Sambandan TJ","year":"2011","journal-title":"Natl J Integr Res Med"},{"key":"e_1_2_8_4_1","unstructured":"PizzornoJ MurrayM.Textbook of natural medicine. 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