{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:47:54Z","timestamp":1787021274687,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T00:00:00Z","timestamp":1467158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["2014A020212089"],"award-info":[{"award-number":["2014A020212089"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2014A030310076"],"award-info":[{"award-number":["2014A030310076"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MALAT<\/jats:styled-content>1 is recognized as an oncogenic lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> in various malignancies. However, its expression and function in oral tongue squamous cell carcinoma are still unknown. This study aims to investigate the expression and function of <jats:styled-content style=\"fixed-case\">MALAT<\/jats:styled-content>1 in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> tissues and cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content> was performed to detect the expression of <jats:styled-content style=\"fixed-case\">MALAT<\/jats:styled-content>1. <jats:styled-content style=\"fixed-case\">MALAT<\/jats:styled-content>1 was suppressed and upregulated by plasmid transfection in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> cells, and then cell migration, invasion, <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>, and apoptosis were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lnc<jats:styled-content style=\"fixed-case\">RNA MALAT<\/jats:styled-content>1 was upregulated in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> tissues and correlated with cervical lymph node metastasis in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> patients. Moreover, <jats:styled-content style=\"fixed-case\">MALAT<\/jats:styled-content>1 induced cell migration, invasion, <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>, and inhibited apoptosis by modulating Wnt\/\u03b2\u2010catenin signaling pathway. Finally, inhibiting Wnt\/\u03b2\u2010catenin signaling pathway attenuated the effect of exogenous <jats:styled-content style=\"fixed-case\">MALAT<\/jats:styled-content>1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, upregulated <jats:styled-content style=\"fixed-case\">MALAT<\/jats:styled-content>1 in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> promoted <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content> and inhibited cell apoptosis by modulating Wnt\/\u03b2\u2010catenin signaling pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12466","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T12:28:37Z","timestamp":1467203317000},"page":"98-105","source":"Crossref","is-referenced-by-count":100,"title":["<scp>MALAT<\/scp>1 induces tongue cancer cells' <scp>EMT<\/scp> and inhibits apoptosis through Wnt\/\u03b2\u2010catenin signaling pathway"],"prefix":"10.1111","volume":"46","author":[{"given":"Jun","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Fifth Affiliated Hospital of Sun Yat\u2010sen University Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Fifth Affiliated Hospital of Sun Yat\u2010sen University Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexiong","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Stomatological Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The Affiliated Stomatological Hospital of Southern Medical University &amp; Guangdong Provincial Stomatological Hospital Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianping","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Pathology Fifth Affiliated Hospital of Sun Yat\u2010sen University Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930115)71:2<452::AID-CNCR2820710228>3.0.CO;2-B"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209808"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.148.1.173"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1028-y"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206928"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-163"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2006.00147.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209846"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21328"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.10.008"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12499"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.04.017"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14034655"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800937"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.1254"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15972"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2mb25070e"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515613507"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo_00000761"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1455"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5MB00685F"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2931"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.08.028"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmq008"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.08.044"}],"container-title":["Journal of Oral Pathology &amp; 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