{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:46:38Z","timestamp":1782776798872,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["132.594"],"award-info":[{"award-number":["132.594"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The number of studies investigating the immunohistochemical characteristics of glandular odontogenic cysts (<jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content>s) is limited, due to its rarity. <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010beta has been suggested to induce podoplanin expression in some lesions. We aimed to evaluate and compare podoplanin and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010beta expression in <jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content> and other odontogenic cystic lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 43 samples including five <jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content>s, 10 dentigerous cysts (<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s), eight unicystic ameloblastoma (<jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>s), and 20 radicular cysts (<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>s) were selected and subjected to immunohistochemical staining using monoclonal antibodies against podoplanin and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010beta. Kruskal\u2013Wallis test and Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test were used for statistical analysis along with Bonferroni for adjusting <jats:italic>P<\/jats:italic>\u2010values (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Podoplanin immunoreactivity was observed in 80%, 70%, and 100% of <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s, <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>s, and <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>s, respectively, while none of the <jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content>s were positive for this marker (<jats:italic>P<\/jats:italic> = 0.004). Significant differences were only found in the <jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content> specimens. <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010beta positivity occurred in the capsule and epithelium of all <jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s, while <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>s demonstrated different expression percentages in the capsular and epithelial tissues. Epithelial <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010beta showed significant differences among the studied lesions (<jats:italic>P<\/jats:italic> = 0.007) with the main difference found between <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s with <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>s with <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lack of podoplanin expression might be involved in the characteristic histologic and behavioral features of <jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content>, which seems to be unrelated to <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010beta expression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12475","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T12:00:39Z","timestamp":1467979239000},"page":"76-80","source":"Crossref","is-referenced-by-count":17,"title":["Expression of podoplanin and <scp>TGF<\/scp>\u2010beta in glandular odontogenic cyst and its comparison with developmental and inflammatory odontogenic cystic lesions"],"prefix":"10.1111","volume":"46","author":[{"given":"Mojgan","family":"Alaeddini","sequence":"first","affiliation":[{"name":"Dental Research Center Dentistry Research Institute Tehran University of Medical Science Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nosratollah","family":"Eshghyar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology Tehran University of Medical Sciences Tehran 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