{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:17:57Z","timestamp":1785345477178,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","award":["RP 002C\u201013 HTM"],"award-info":[{"award-number":["RP 002C\u201013 HTM"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Lymph node metastasis in oral squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>) is a well\u2010known independent prognostic factor. However, the identification of occult tumour cells within the lymph nodes has remained a challenge for the pathologist as well as the clinician.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to determine the prevalence of micrometastasis and isolated tumour cells (<jats:styled-content style=\"fixed-case\">ITC<\/jats:styled-content>s) in pathologically staged N0 <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> of the tongue and buccal mucosa and to assess its correlation with vascular endothelial growth factor C, (VEGF\u2010C) expression in the primary tumour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010four cases of N0 <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> comprising of 17 cases each from the tongue and buccal mucosa were evaluated by immunohistochemistry for <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010C expression. The corresponding lymph nodes from levels I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> were pathologically examined and cross\u2010detected for micrometastasis and <jats:styled-content style=\"fixed-case\">ITC<\/jats:styled-content>s with desmoglein 3 (<jats:styled-content style=\"fixed-case\">DSG<\/jats:styled-content>3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of micrometastasis and <jats:styled-content style=\"fixed-case\">ITC<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> of the tongue and buccal mucosa was 23.5% and 17.6%, respectively. A total of 12 out of 151 lymph nodes contained micrometastatic tumour foci and <jats:styled-content style=\"fixed-case\">ITC<\/jats:styled-content>s. A higher expression of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010C in the primary tumour was associated with a greater probability for the occurrence of micrometastasis and <jats:styled-content style=\"fixed-case\">ITC<\/jats:styled-content>s in the lymph nodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High expression of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010C in the primary tumour may be a good determinant for detection of occult tumour cells in the lymph nodes of <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12476","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T09:12:24Z","timestamp":1468573944000},"page":"194-200","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic significance of <scp>VEGF<\/scp>\u2010C in predicting micrometastasis and isolated tumour cells in N0 oral squamous cell carcinoma"],"prefix":"10.1111","volume":"46","author":[{"given":"Sarvambika","family":"Kazakydasan","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Clinical Sciences Faculty of Dentistry University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainal Ariff Abdul","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Clinical Sciences Faculty of Dentistry University of Malaya Kuala Lumpur Malaysia"},{"name":"Oral Cancer Research and Coordinating Centre Faculty of Dentistry University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti Mazlipah","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Clinical Sciences Faculty of Dentistry University of Malaya Kuala Lumpur Malaysia"},{"name":"Oral Cancer Research and Coordinating 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