{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:32:43Z","timestamp":1769013163230,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T00:00:00Z","timestamp":1470787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["FAPESP 2015\/21520\u20108"],"award-info":[{"award-number":["FAPESP 2015\/21520\u20108"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["FAPESP 2015\/16056\u20100"],"award-info":[{"award-number":["FAPESP 2015\/16056\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Different environmental agents may cause <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> mutations by disrupting its double\u2010strand structure; however, even normal <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> polymerase function may synthesize mismatch nucleotide bases, occasionally demonstrating failure in its proofreading activity. To overcome this issue, mismatch repair (<jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content>) system, a group of proteins specialized in finding mispairing bases and small loops of insertion or deletion, works to avoid the occurrence of mutations that could ultimately lead to innumerous human diseases. In the last decades, the role of <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> proteins in oral carcinogenesis and in the development of other oral cavity neoplasms has grown, but their importance in the pathogenesis and their prognostic potential for patients affected by oral malignancies, especially oral squamous cell carcinoma (OSCC), remain unclear. Therefore, in this manuscript we aimed to review and critically discuss the currently available data on <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> proteins expression in oral potentially malignant lesions, in OSCC, and in other oral neoplasms to better understand their relevance in these lesions.<\/jats:p>","DOI":"10.1111\/jop.12484","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T15:53:54Z","timestamp":1470844434000},"page":"241-245","source":"Crossref","is-referenced-by-count":26,"title":["Mismatch repair system proteins in oral benign and malignant lesions"],"prefix":"10.1111","volume":"46","author":[{"given":"Gleyson Kleber do","family":"Amaral\u2010Silva","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School University of Campinas Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoela Domingues","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Dentistry Federal University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lder Ant\u00f4nio Rebelo","family":"Pontes","sequence":"additional","affiliation":[{"name":"Service of Buccal Pathology Jo\u00e3o de Barros Barreto University Hospital Federal University of Par\u00e1 Bel\u00e9m Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Rodrigues","family":"Fregnani","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine S\u00edrio\u2010Liban\u00eas Hospital S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio Ajudarte","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School University of Campinas Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Paiva","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School University of Campinas Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo Agustin","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School University of Campinas Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2015.12.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(90)90021-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2010.10.009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00252-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2008.02.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.65.070196.000533"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(99)80013-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/71643"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389202911314020002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R600022200"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2014.03.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-004-7993-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.09.011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-016-0130-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2141-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2014_83"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00963.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.01000.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.06.017"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22430"},{"key":"e_1_2_7_22_1","first-page":"2433","article-title":"Tobacco and inflammation effects in immunoexpression of hMSH2 and hMLH1 in epithelium of oral mucosa","volume":"27","author":"Fernandes AM","year":"2007","journal-title":"Anticancer Res"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12197"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12144"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03756.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202411"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31820fe1cb"},{"key":"e_1_2_7_28_1","first-page":"933","article-title":"Immunocytochemical detection of hMSH2 and hMLH1 expression in oral SCC","volume":"19","author":"Lo Muzio L","year":"1999","journal-title":"Anticancer Res"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.08.024"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01510.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.10.002"},{"key":"e_1_2_7_32_1","first-page":"528","article-title":"EL\u2010SHERBINY YM. Head and neck squamous cell carcinoma: mismatch repair immunohistochemistry and promoter hypermethylation of hMLH1 gene","volume":"32","author":"Tawfik HM","year":"2011","journal-title":"Am J Otolaryngol"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1337"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.05.014"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056952"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29435"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(98)00157-8"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm_00000017"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003725"},{"key":"e_1_2_7_40_1","first-page":"921","article-title":"Loss of DNA\u2010mismatch repair gene expression in oral melanomas","volume":"6","author":"Korabiowska M","year":"1999","journal-title":"Oncol Rep"},{"key":"e_1_2_7_41_1","first-page":"741","article-title":"Immunocytochemical detection of hMSH2 and hMLH1 expression in oral melanoma","volume":"20","author":"Lo Muzio L","year":"2000","journal-title":"Anticancer Res"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.02.033"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2001.0161"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2002.310407.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300508.x"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12484","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:29:45Z","timestamp":1696177785000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,10]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/jop.12484"],"URL":"https:\/\/doi.org\/10.1111\/jop.12484","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,10]]}}}