{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T02:09:38Z","timestamp":1774404578468,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T00:00:00Z","timestamp":1473206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science and Technology, ROC","award":["102-2314-B-002-125-MY3"],"award-info":[{"award-number":["102-2314-B-002-125-MY3"]}]},{"name":"Ministry of Science and Technology, ROC","award":["105-2314-B-002-075-MY2"],"award-info":[{"award-number":["105-2314-B-002-075-MY2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Background<\/jats:title>Desquamative gingivitis (DG<\/jats:styled-content>) is principally associated with erosive oral lichen planus (EOLP<\/jats:styled-content>), mucous membrane pemphigoid (MMP<\/jats:styled-content>), and pemphigus vulgaris (PV<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Serum autoantibodies including antigastric parietal cell antibody (GPCA<\/jats:styled-content>), antithyroglobulin antibody (TGA<\/jats:styled-content>), and antithyroid microsomal antibody (TMA<\/jats:styled-content>) were measured in 500 patients with DG<\/jats:styled-content>, 287 EOLP<\/jats:styled-content> without DG<\/jats:styled-content> (EOLP<\/jats:styled-content>\/DG<\/jats:styled-content>\u2212<\/jats:sup>) patients, and 100 healthy control subjects.<\/jats:p><\/jats:sec>Results<\/jats:title>The 500 patients with DG<\/jats:styled-content> were diagnosed as having EOLP<\/jats:styled-content> in 455 (91%), PV<\/jats:styled-content> in 40 (8%), and MMP<\/jats:styled-content> in five (1%) patients. We found that 37.0%, 43.6%, and 42.6% of 500 patients with DG<\/jats:styled-content>, 39.6%, 46.4%, and 45.1% of 455 EOLP<\/jats:styled-content> with DG<\/jats:styled-content> (EOLP<\/jats:styled-content>\/DG<\/jats:styled-content>) patients, and 18.5%, 27.5%, and 30.3% of 287 EOLP<\/jats:styled-content>\/DG<\/jats:styled-content>\u2212<\/jats:sup> patients had the presence of GPCA<\/jats:styled-content>, TGA<\/jats:styled-content>, and TMA<\/jats:styled-content> in their sera, respectively. DG<\/jats:styled-content>, EOLP<\/jats:styled-content>\/DG<\/jats:styled-content>, and EOLP<\/jats:styled-content>\/DG<\/jats:styled-content>\u2212<\/jats:sup> patients all had a significantly higher frequency of GPCA<\/jats:styled-content>, TGA<\/jats:styled-content>, or TMA<\/jats:styled-content> positivity than healthy control subjects (all P<\/jats:italic>\u2010values < 0.001). Moreover, 455 EOLP<\/jats:styled-content>\/DG<\/jats:styled-content> patients had a significantly higher frequency of GPCA<\/jats:styled-content>, TGA<\/jats:styled-content>, or TMA<\/jats:styled-content> positivity than 287 EOLP<\/jats:styled-content>\/DG<\/jats:styled-content>\u2212<\/jats:sup> patients (all P<\/jats:italic>\u2010values < 0.001). Of 210 TGA<\/jats:styled-content>\/TMA<\/jats:styled-content>\u2010positive patients with DG<\/jats:styled-content> whose serum thyroid\u2010stimulating hormone (TSH<\/jats:styled-content>) levels were measured, 84.3%, 6.7%, and 9.0% patients had normal, lower, and higher serum TSH<\/jats:styled-content> levels, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We conclude that 73.4% DG<\/jats:styled-content>, 77.1% EOLP<\/jats:styled-content>\/DG<\/jats:styled-content>, and 47.4% EOLP<\/jats:styled-content>\/DG<\/jats:styled-content>\u2212<\/jats:sup> patients may have GPCA<\/jats:styled-content>\/TGA<\/jats:styled-content>\/TMA<\/jats:styled-content> positivity in their sera. Because part of GPCA<\/jats:styled-content>\u2010positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA<\/jats:styled-content>\/TMA<\/jats:styled-content>\u2010positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12490","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T17:17:24Z","timestamp":1473268644000},"page":"307-312","source":"Crossref","is-referenced-by-count":49,"title":["Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis"],"prefix":"10.1111","volume":"46","author":[{"given":"Julia Yu\u2010Fong","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Clinical Dentistry and Graduate Institute of Oral Biology School of Dentistry National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Pin","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Clinical Dentistry and Graduate Institute of Oral Biology School of Dentistry National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Clinical Dentistry and Graduate Institute of Oral Biology School of Dentistry National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang\u2010Che","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Clinical Dentistry and Graduate Institute of Oral Biology School of Dentistry National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12021"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1610-0387.2010.07543.x","article-title":"Desquamative gingivitis as a manifestation of chronic mucocutaneous disease","volume":"9","author":"Gagari E","year":"2011","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04142.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2007.01420.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.3.482"},{"key":"e_1_2_5_7_1","first-page":"381","article-title":"Chronic desquamative gingivitis syndrome: retrospective analysis of 33 cases","volume":"127","author":"Vaillant L","year":"2000","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.6.678"},{"key":"e_1_2_5_9_1","first-page":"763","article-title":"Desquamative gingivitis: a clinical, histopathologic, and immunologic study","volume":"27","author":"Markopoulos AK","year":"1996","journal-title":"Quintessence Int"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(83)90278-5"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)70153-7"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90080-9"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1981.52.9.500"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(60)90292-9"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i30.4715"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2009.00395.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2012.04.003"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607113350206"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2014.10.004"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01122.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00686.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb01988.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12014"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-003-0412-9"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/146897"},{"key":"e_1_2_5_26_1","first-page":"307","article-title":"Prevalence of thyroid autoimmunity in patients with pemphigus vulgaris","volume":"65","author":"Pitoia F","year":"2005","journal-title":"Medicina (B Aires)"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03172.x"}],"container-title":["Journal of Oral Pathology & Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12490","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12490","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:29:23Z","timestamp":1696177763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,7]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/jop.12490"],"URL":"https:\/\/doi.org\/10.1111\/jop.12490","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,7]]}}}