{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:47:29Z","timestamp":1791218849976,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271110"],"award-info":[{"award-number":["81271110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16411961202"],"award-info":[{"award-number":["16411961202"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To compare the effects of Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> in combination with concentrated growth factors (<jats:styled-content style=\"fixed-case\">CGF<\/jats:styled-content>s) and bone marrow\u2010derived mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s) on bone regeneration for maxillary sinus floor augmentation in beagle dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six beagle dogs received bilateral maxillary sinus floor augmentation. Venous blood drawn from dogs was collected and centrifuged to obtain <jats:styled-content style=\"fixed-case\">CGF<\/jats:styled-content>s. <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s derived from canine bone marrow were cultured using density gradient centrifugation. The suspension of <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s was added onto Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> granules at a density of 2 \u00d7 10<jats:sup>6<\/jats:sup> cells\/ml, and the <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s\/Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> constructs were incubated for an additional 4 h before use. Twelve sinuses were grafted with a mixture of <jats:styled-content style=\"fixed-case\">CGF<\/jats:styled-content>s\/Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup>, <jats:styled-content style=\"fixed-case\">BMSC<\/jats:styled-content>s\/Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> construct, or Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> alone. Six months later, the bone formation of bilateral sinuses was evaluated by Micro\u2010CT, microhardness test, histological examination, and histomorphometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No adverse effect was found in these dogs. The dome\u2010shaped augmentation protruded into the sinus cavity. Micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> revealed that there was significant difference in <jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content> but not in Tb. N, between groups A, B, and C. The extent of microhardness in groups A and B was significantly higher than in group C. The proportion of newly formed bone in groups A and B showed significant difference when compared to group C (<jats:italic>P<\/jats:italic> \u2264 0.01). The amount of residual grafts in groups A and B was significantly lower than in group C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Grafting with Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> in combination with <jats:styled-content style=\"fixed-case\">CGF<\/jats:styled-content>s can increase new bone formation more efficiently than using Bio\u2010Oss<jats:sup>\u00ae<\/jats:sup> alone in a canine model.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12507","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T14:09:06Z","timestamp":1475071746000},"page":"528-536","source":"Crossref","is-referenced-by-count":41,"title":["A comparative study of the effect of Bio\u2010Oss<sup>\u00ae<\/sup> in combination with concentrated growth factors or bone marrow\u2010derived mesenchymal stem cells in canine sinus 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