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This study aimed to outline adverse effects of new targeted cancer therapies on oral cavity including dental abnormalities observed in pediatric population treated with these molecules and the risk of osteonecrosis of the jaw (<jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content>). The impact of bisphosphonates and denosumab on bone remodeling (inhibition of osteoclasts) could interfere with teeth exfoliation and eruption processes, causing a tooth eruption delay. This hypothesis was confirmed, bisphosphonate\u2010treated rats presented tooth eruption delay, and bisphosphonate therapy was associated with a mean delay of 1.67 years in tooth eruption in children with osteogenesis imperfecta. Another study showed that the inhibition of <jats:styled-content style=\"fixed-case\">RANK<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content> by denosumab was associated with a lack of tooth eruption in animals. Several animal studies reported that bisphosphonate could also induce dental abnormalities including defective amelogenesis and dentinogenesis in rats, but there is no evidence of such effects in children; only one case of enamel hypoplasia in a child treated for idiopathic arterial calcification with bisphosphate was reported. To date, there has been no reported case of <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content> in children treated with bisphosphonates, denosumab, or bevacizumab.<\/jats:p>","DOI":"10.1111\/jop.12516","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T07:36:38Z","timestamp":1477380998000},"page":"321-326","source":"Crossref","is-referenced-by-count":23,"title":["Use of new targeted cancer therapies in children: effects on dental development and risk of jaw osteonecrosis: a review"],"prefix":"10.1111","volume":"46","author":[{"given":"Magali","family":"Hernandez","sequence":"first","affiliation":[{"name":"Pediatric Dentistry Department CHRU of Nancy Vandoeuvre\u2010les\u2010Nancy France"},{"name":"Pediatric Dentistry Department Faculty of Dentistry Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9reng\u00e8re","family":"Phulpin","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery and Dental Units Oncology Surgery Department Institute of Cancerology of Lorraine Vandoeuvre\u2010l\u00e8s\u2010Nancy France"},{"name":"Oral Surgery Department Faculty of Dentistry Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Mansuy","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Department CHRU of Nancy Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Droz","sequence":"additional","affiliation":[{"name":"Pediatric Dentistry Department CHRU of Nancy Vandoeuvre\u2010les\u2010Nancy France"},{"name":"Pediatric Dentistry Department Faculty of Dentistry Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,14]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2010.02.003"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2015.193"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24842"},{"key":"e_1_2_4_5_1","first-page":"22","article-title":"Mechanisms of action of bisphosphonates on tumor cells and prospects for use in the treatment of malignant osteolysis","volume":"67","author":"Clezardin P","year":"2000","journal-title":"Joint Bone Spine"},{"key":"e_1_2_4_6_1","unstructured":"GuillaumeA OdriMD CorradiniN R\u00e9diniF.Combination of zelodronic acid with chemotherapy in mouse: preclinical models of Ewing's sarcoma. 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