{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:47:08Z","timestamp":1769078828441,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study investigated the effects of mesenchymal stem cell (<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>) sheet transplantation on healing of chemically induced oral ulceration in a rabbit animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Oral mucosal ulcers were induced by topical application of filter paper soaked with 70% acetic acid to the anterior gingiva and buccal mucosa of 12 New Zealand white rabbits. The animals were randomly assigned to two groups: with (treatment group,<jats:italic>n<\/jats:italic>= 6) or without (control group,<jats:italic>n<\/jats:italic>= 6) cell sheets applied to ulcers. Gross findings were sequentially evaluated, and histologic examination was performed on day 7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on gross inspection, ulceration resolved before day 5 in the treatment group; however, in the control group, healing was incomplete on day 7. In the treatment group, the total area of the ulcer decreased significantly from day 2 to day 5 (<jats:italic>P<\/jats:italic>&lt; 0.001) and from day 5 to day 7 (<jats:italic>P<\/jats:italic>= 0.020), whereas the area decreased significantly from day 5 to day 7 in the control group (<jats:italic>P<\/jats:italic>&lt; 0.001). Histologic and immunofluorescence examination revealed full\u2010thickness mucosa healing and complete basal cell coverage in the treatment group; in contrast, only partial healing was observed on day 7 in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cell sheet technology using<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>can be an alternative treatment for oral ulcerations in that it can decrease healing time without invasive properties.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12517","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T16:46:53Z","timestamp":1480006013000},"page":"520-527","source":"Crossref","is-referenced-by-count":33,"title":["Treatment of chemically induced oral ulcer using adipose\u2010derived mesenchymal stem cell sheet"],"prefix":"10.1111","volume":"46","author":[{"given":"Doh Young","family":"Lee","sequence":"first","affiliation":[{"name":"Department 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