{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:19:22Z","timestamp":1783073962411,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A study was conducted to develop and validate a screening model using risk scores to identify individuals at high risk for developing upper aerodigestive tract (<jats:styled-content style=\"fixed-case\">UADT<\/jats:styled-content>) cancers in an Indian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A hospital\u2010based case\u2013control study (<jats:italic>n<\/jats:italic> = 480) was conducted in Pune, India. We assessed risk factors for <jats:styled-content style=\"fixed-case\">UADT<\/jats:styled-content> cancers by administering a questionnaire through face\u2010to\u2010face interviews. We developed a risk factor model based on the statistically significant risk factors in multiple logistic regression. A total, single risk score was calculated per individual based on the adjusted odds ratio for each of their risk factors. Standard receiver operator characteristic curve was plotted for the total score and the presence of <jats:styled-content style=\"fixed-case\">UADT<\/jats:styled-content> cancers. The stratification ability of the model was determined using the c\u2010statistic. The optimal criterion value was determined at the point on curve at which the Youden's index was maximal. Confidence intervals were calculated by bootstrapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total risk score for each individual ranged from 0 to 26. Area under the receiver operating characteristic curve (95.8; <jats:italic>P<\/jats:italic> &lt; 0.001) suggests strong predictive ability. A risk score criterion value of \u226410 produced optimal sensitivity (93.5%), specificity (71.1%), false\u2010positive rate (28.8%), false\u2010negative rate (6.4%), positive predictive value (74.8%), and negative predictive value (96.6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This risk factor\u2010based model has the potential of satisfactorily screening and detection of <jats:styled-content style=\"fixed-case\">UADT<\/jats:styled-content> cancers at its early stage in a high\u2010risk population like India. The identified at\u2010risk individuals can then be targeted for clinical examination and for focused preventive\/treatment measures at the hospital.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12520","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T16:37:40Z","timestamp":1478536660000},"page":"465-471","source":"Crossref","is-referenced-by-count":10,"title":["A risk factor\u2010based model for upper aerodigestive tract cancers in India: predicting and validating the receiver operating characteristic curve"],"prefix":"10.1111","volume":"46","author":[{"given":"Bhawna","family":"Gupta","sequence":"first","affiliation":[{"name":"School of Dentistry and Oral Health Menzies Health Institute Queensland Griffith University Gold Coast Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narinder","family":"Kumar","sequence":"additional","affiliation":[{"name":"Military Hospital Kirkee Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Newell W.","family":"Johnson","sequence":"additional","affiliation":[{"name":"School of Dentistry and Oral Health Menzies Health Institute Queensland Griffith University Gold Coast Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_5_3_1","unstructured":"National Cancer Registry Programme.Three\u2010Year Report of Population Based cancer Registries 2009\u20132011 Bangalore Indian Council of Medical Research 2013."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446117"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2013.09.018"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.06.002"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/29.4.609"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10200"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12192"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.15.5983"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn172"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-016-0475-7"},{"key":"e_1_2_5_13_1","first-page":"2","article-title":"The lifegrid method of collecting retrospective information from people at older ages","volume":"21","author":"Berney L","year":"2003","journal-title":"Res Policy Plan"},{"key":"e_1_2_5_14_1","volume-title":"Smokeless tobacco and some tobacco\u2010specific N\u2010nitrosamines. 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