{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T14:16:53Z","timestamp":1761401813163},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,11,27]],"date-time":"2016-11-27T00:00:00Z","timestamp":1480204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) is a chronic, inflammatory disorder that affects the oral mucous membrane. During an inflammatory response, several chemokines and cytokines are released by the cells of the immune system. Activation of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s, along with mast cell\u2010derived chymase and tryptase, degrades the basement membrane structural proteins, resulting in basement membrane breaks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the association between the <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 expressions, presence of intact or degranulating mast cells within the connective tissue and the extent of basement membrane discontinuity in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included a total of 50 formalin\u2010fixed paraffin\u2010embedded specimens (<jats:styled-content style=\"fixed-case\">FFPE<\/jats:styled-content>) of histologically confirmed cases of idiopathic oral lichen planus. A retrospective cross\u2010sectional analysis was carried out by immunohistochemistry to study the epithelial expression of <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 and by the use of special stains such as toluidine blue and periodic acid\u2013Schiff (<jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content>) to study the mast cell count and basement membrane changes in the oral mucosal tissue, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant (<jats:italic>P<\/jats:italic> = 0.03) association between the <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 expressions and mast cell count. As the intensity of <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 expression increased from mild to moderate or severe, the number of mast cell count almost doubled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Interaction between upregulation of <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102, mast cell and basement membrane sets a vicious cycle which relates to the chronic nature of the disease. Inhibitors of <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 may reduce the inflammatory process preceding the immune dysregulation in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12521","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T16:14:12Z","timestamp":1478535252000},"page":"381-386","source":"Crossref","is-referenced-by-count":7,"title":["Elucidating the role of Cyclooxygenase\u20102 in the pathogenesis of oral lichen planus \u2013 an immunohistochemical study with supportive histochemical analysis"],"prefix":"10.1111","volume":"46","author":[{"given":"Pratyush","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology Manipal College of Dental Sciences Manipal University Manipal Karnataka 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