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Although the latter can improve regional control, it does not reduce overall survival. Elective neck dissection is recommended for nodular oral mucosal melanoma, but its role in the clinically node negative neck is controversial. Systemic therapies including the use of tyrosine kinase inhibitors for tumours with c\u2010<jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content> mutations are suitable for patients with advanced loco\u2010regional and\/or metastatic disease, but current results are variable. Patients with head and neck mucosal melanoma have a poor prognosis due to the high incidence of metastatic disease. This review assesses the latest evidence in the diagnosis and management of primary oral and head and neck mucosal melanoma including details of systemic therapies.<\/jats:p>","DOI":"10.1111\/jop.12526","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T12:22:39Z","timestamp":1479558159000},"page":"475-479","source":"Crossref","is-referenced-by-count":22,"title":["An update on the current management of head and neck mucosal melanoma"],"prefix":"10.1111","volume":"46","author":[{"given":"Ben","family":"Green","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Torbay Hospital Torquay UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elhamshary","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Queen Alexandra Hospital Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery &amp; Pathology School of Dentistry Universidade Federal de Minas Gerais\u2010UFMG Belo\u2010Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siavash","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Department of Histopathology Queen Alexandra Hospital Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Queen Alexandra Hospital Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,10]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2016.03.008"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1998.00099.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2016.1143117"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181a0d37c"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3283374d31"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890040509"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2014.1175"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.08.987"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000170805.14058.d3"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24976"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23872"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2013.11.004"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.01.008"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.153"},{"key":"e_1_2_4_16_1","first-page":"726","article-title":"Analysis of c\u2010KIT expression and KIT gene mutation in human mucosal melanomas","volume":"21","author":"Satzger I","year":"2008","journal-title":"Br J Cancer"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000035"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.01.025"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2005.03343.x"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12692"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-30629-3_2"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21984"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2011.04.013"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200106000-00010"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000220"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02683.x"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(70)80001-0"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20201"},{"key":"e_1_2_4_29_1","volume-title":"International Union Against Cancer (UICC). 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