{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T13:06:32Z","timestamp":1761311192956},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T00:00:00Z","timestamp":1482537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/05062\u20101"],"award-info":[{"award-number":["2012\/05062\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The genotoxic impact of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection on the oral cavity malignancies is unknown. The aim of this study was to evaluate the effect of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection in micronucleus (<jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content>) frequency on the oral mucosa of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>+ patients and establish a relationship with early cytogenetic changes in oral carcinogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>+ individuals who are under highly active antiretroviral therapy (<jats:styled-content style=\"fixed-case\">HAART<\/jats:styled-content>) and 30 non\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients were evaluated. Two smears were taken from the lateral border of the tongue and mouth floor and stained by Feulgen. The frequency of <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content> was examined in 3000 cells per subject under common microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content> analysis showed no significant difference between groups by Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test for total <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content>s (<jats:italic>P<\/jats:italic> = 0.178). The presence of single <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content> was greater in control group with statistical significance (<jats:italic>P<\/jats:italic> = 0.009), while in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> group, multiple <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content>s were exhibited in higher mean.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients under <jats:styled-content style=\"fixed-case\">HAART<\/jats:styled-content> therapy and low viral load values showed higher frequency of multiple <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content>s, which, although not statistically significant, may be caused by the action of the Vpr gene, an accessory gene of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>. These results corroborate the theory of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection cytogenetic damage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12527","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T07:12:39Z","timestamp":1479798759000},"page":"644-648","source":"Crossref","is-referenced-by-count":9,"title":["Effect of HIV infection in the micronuclei frequency on the oral mucosa"],"prefix":"10.1111","volume":"46","author":[{"given":"Celina Faig","family":"Lima","sequence":"first","affiliation":[{"name":"University Braz Cubas Mogi das Cruzes, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica Ghislaine Oliveira","family":"Alves","sequence":"additional","affiliation":[{"name":"University Braz Cubas Mogi das Cruzes, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juvencio Jose Duailibe","family":"Furtado","sequence":"additional","affiliation":[{"name":"Department of Infectology Heliopolis Hospital S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Marcucci","sequence":"additional","affiliation":[{"name":"Department of Stomatology Heliopolis Hospital S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Balducci","sequence":"additional","affiliation":[{"name":"Department of Social and Pediatric Dentistry S\u00e3o Paulo State University (Unesp) Institute of Science and Technology S\u00e3o Jos\u00e9 dos Campos, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janete Dias","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Oral Diagnosis S\u00e3o Paulo State University (Unesp) Institute of Science and Technology S\u00e3o Jos\u00e9 dos Campos, S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.53.203"},{"key":"e_1_2_5_3_1","unstructured":"WHO.Global update on the health sector response to HIV 2014 July 2014.Geneva Switzerland;World Health Organization (2014). 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