{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T15:02:46Z","timestamp":1784991766645,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> repair systems play a critical role in protecting the human genome from damage caused by carcinogens. Modifications in <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> repair genes may be responsible for tumor development and resistance of malignant cells to chemotherapeutic agents. The major pathway for oxidative <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage repair is the base excision repair pathway. This study aimed to assess the immunoexpression of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> repair proteins <jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>\u20101 and its association with clinical, histologic, and survival parameters in oral tongue squamous cell carcinoma, to investigate a possible role for those proteins in tumor behavior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The expression of <jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>\u20101 was evaluated by immunohistochemistry in 82 cases of oral tongue squamous cell carcinoma. Histopathological grading was performed for each case. Pearson's chi\u2010square and Fisher's exact tests were used to determine the association between protein expressions and clinicopathological features of tumors, whereas Kaplan\u2013Meier curves and Cox regression were used to analyze disease\u2010specific and disease\u2010free survival. Statistical significance was set at <jats:italic>P<\/jats:italic> \u2264 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>APE\u20101 was highly expressed in the nucleus and cytoplasm in 64.6% of cases, and XRCC\u20101 showed overexpression only in the nucleus in 61% of cases. High expression of <jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>\u20101 was significantly associated with tumors at early clinical stages (I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>,<jats:italic> P<\/jats:italic> &lt; 0.01) and nodal status (<jats:italic>P<\/jats:italic> = 0.03). Both proteins were not associated with other clinical parameters, histopathological grading, or survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> base excision repair proteins <jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>\u20101 are upregulated in oral tongue squamous cell carcinoma, and <jats:styled-content style=\"fixed-case\">XRCC<\/jats:styled-content>\u20101 expression is associated with better clinical staging and nodal status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12529","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T14:52:43Z","timestamp":1481122363000},"page":"496-503","source":"Crossref","is-referenced-by-count":20,"title":["<scp>DNA<\/scp> base excision repair proteins <scp>APE<\/scp>\u20101 and <scp>XRCC<\/scp>\u20101 are overexpressed in oral tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"46","author":[{"given":"Thalita","family":"Santana","sequence":"first","affiliation":[{"name":"Oral Pathology Post Graduate Program Department of Dentistry Federal University of Rio Grande do Norte Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melka Co\u00ealho","family":"S\u00e1","sequence":"additional","affiliation":[{"name":"Oral Pathology Post Graduate Program Department of Dentistry Federal University of Rio Grande do Norte Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edilmar","family":"de Moura Santos","sequence":"additional","affiliation":[{"name":"Oral Pathology Post Graduate Program Department of Dentistry Federal University of Rio Grande do Norte Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9bel Cavalcanti","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Oral Pathology Post Graduate Program Department of Dentistry Federal University of Rio Grande do Norte Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo D.","family":"Coletta","sequence":"additional","affiliation":[{"name":"Oral Diagnosis School of Dentistry State University of Campinas Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseana de Almeida","family":"Freitas","sequence":"additional","affiliation":[{"name":"Oral Pathology Post Graduate Program Department of Dentistry Federal University of Rio Grande do Norte Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00401.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23583"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23927"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12197"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2015.12.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-8736-z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2007.01.009"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2194"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.367"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3100"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki543"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2015.05.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102112"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099528"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2014.074"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-1792-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23422"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-014-2562-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000149687.90710.21"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2218"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)01561-3"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03756.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-010-0102-0"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl177"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00057.2013"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S75152"},{"key":"e_1_2_6_28_1","volume-title":"World Health Organization Classification of Tumours","author":"Barnes L.","year":"2005"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-1604"},{"key":"e_1_2_6_30_1","first-page":"47","article-title":"Expression of XRCC 1 and ERCC 1 proteins in radioresistant and radiosensitive laryngeal cancer","volume":"2","author":"Nix P","year":"2004","journal-title":"Cancer Ther"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2863"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2013.85"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12529","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:03:12Z","timestamp":1695488592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,23]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/jop.12529"],"URL":"https:\/\/doi.org\/10.1111\/jop.12529","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,23]]}}}