{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:08:59Z","timestamp":1758121739904,"version":"3.41.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T00:00:00Z","timestamp":1482537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Human T\u2010lymphotropic virus type I (<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I) is known to be associated with neoplastic and neurodegenerative changes, and it is believed to be associated with various systemic inflammatory diseases, including Sj\u00f6gren's syndrome (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>). Although<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I infection is endemic in Brazil, there is no information regarding the association between<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I infection and<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>in the Brazilian population. The objective of this study was to determine the prevalence of<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>in<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I\u2010infected individuals and the prevalence of<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I infection in individuals diagnosed with<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serology for<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I was performed in 50 patients presenting with complaints consistent with<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>(the<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>group). The<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I group comprised 129<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I\u2010infected patients who were screened for<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the patients in the<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>group tested positive for<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I. Of the 129 patients in the<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I group, 46 (35.7%) had xerostomia, 18 (13.95%) had xerophthalmia, eight (6.2%) had hyposalivation, two (1.55%) showed impaired tear secretion, and one (0.77%) was positive for autoantibodies (anti\u2010<jats:styled-content style=\"fixed-case\">SSB<\/jats:styled-content>). In addition, six underwent minor salivary gland biopsy, and the histopathological findings were consistent with<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>. Only two (1.55%) met the diagnostic criteria for<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>was found to be three times as high in<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I\u2010infected individuals as it was in those without<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I infection. However, given the small number of<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010seropositive patients with<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>, it is impossible to state that<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>acts as an immune\u2010activating pathogen for<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12530","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T15:56:41Z","timestamp":1481126201000},"page":"543-548","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of Sj\u00f6gren's syndrome in Brazilian patients infected with human T\u2010cell lymphotropic virus"],"prefix":"10.1111","volume":"46","author":[{"given":"Daniela Assis do","family":"Vale","sequence":"first","affiliation":[{"name":"Special Care Dentistry Center Department of Stomatology School of Dentistry University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Casseb","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine of Sao Paulo University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto C\u00e9sar Penalva","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases \u201cEmilio Ribas\u201d Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Bussoloti Filho","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Irmandade da Santa Casa de Misericordia Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzana Cantanhede Orsini Machado","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Department of Stomatology School of Dentistry University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karem L\u00f3pez","family":"Ortega","sequence":"additional","affiliation":[{"name":"Special Care Dentistry Center Department of Stomatology School of Dentistry University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/300063a0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208970"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70081-6"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/15027732.1986.12461382","article-title":"Labial salivary gland immunopathology in Sjogren's syndrome","volume":"61","author":"Dalavanga YA","year":"1986","journal-title":"Scand J Rheumatol Suppl"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.11.004"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90630-0"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2000.103429"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.6.769"},{"key":"e_1_2_5_12_1","first-page":"121","article-title":"Serologic activity against retrovirus in patients with Sjogren syndrome","volume":"100","author":"Leon\u2010Monzon M","year":"1993","journal-title":"Med Clin (Barc)"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111075"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90994-6"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330603"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb06875.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91200-2"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01638.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-72992002000200010"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2255-5021(13)70003-8"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2006.03.008"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1264"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00675-X"},{"key":"e_1_2_5_25_1","first-page":"1183","article-title":"[Viral Tax protein expression in salivary glands of patients infected with human t\u2010cell lymphotropic virus type I and Sicca Syndrome]","volume":"133","author":"Cartier L","year":"2005","journal-title":"Rev Med Chil"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1066-5"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-95022006000400031"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822009000600004"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0482-50042006000500006"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8402059"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12530","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T07:57:03Z","timestamp":1749801423000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,24]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/jop.12530"],"URL":"https:\/\/doi.org\/10.1111\/jop.12530","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"type":"print","value":"0904-2512"},{"type":"electronic","value":"1600-0714"}],"subject":[],"published":{"date-parts":[[2016,12,24]]}}}