{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:44:23Z","timestamp":1761993863493,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Because of the low proportion of squamous cell carcinomas (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s) of the buccal mucosa within the carcinomas of the oral cavity in the Western population, data concerning metastatic pattern are sparse. Therefore, this retrospective study is focusing on the occurrence of cervical metastases (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>) and the overall outcome of this tumor entity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>From January 1988 to October 2013, 113 patients were treated in the Department of Oral and Maxillofacial Surgery, Mainz, for an oral <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> of the cheek. Metastatic pattern and clinical parameters that are possibly associated with an increased risk for <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> as well as overall outcome were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average follow\u2010up was 48 months (range: 1\u2013248 months). A total of 55 (49%) patients were female and 58 (51%) male, with an average age of 65 \u00b1 13 years (\u264068 \u00b1 14 years; \u264263 \u00b1 11 years). In total, 55% of the patients either smoked and\/or consumed alcohol. In total, 34% of the patients had a stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> tumor, with overall 23% having <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> at the time of diagnosis. During the follow\u2010up, 50% (<jats:italic>n<\/jats:italic> = 56) of the patients developed a relapse after 12 months (median). Tumor size (<jats:italic>P<\/jats:italic> = 0.002*) and grading (<jats:italic>P<\/jats:italic> &lt; 0.001*) are significantly associated with the occurrence of <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>. Metastases (<jats:italic>P<\/jats:italic> = 0.008*) and advanced tumor size (<jats:italic>P<\/jats:italic> = 0.018) had an influence on the survival, whereas the relapse had no significant influence (<jats:italic>P<\/jats:italic> = 0.928). Five\u2010year survival rate was 80%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> of the buccal mucosa shows aggressive behavior with a considerably high proportion of relapse. Since overall outcome is significantly decreased by the cervical metastatic pattern, a selective, ipsilateral neck dissection for this patient group is recommended as the primary management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12537","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T16:46:03Z","timestamp":1481301963000},"page":"460-464","source":"Crossref","is-referenced-by-count":11,"title":["Outcome and cervical metastatic spread of squamous cell cancer of the buccal mucosa, a retrospective analysis of the past 25 years"],"prefix":"10.1111","volume":"46","author":[{"given":"Keyvan","family":"Sagheb","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery \u2013 Plastic Surgery University Medical Center of the Johannes Gutenberg\u2010University Mainz Mainz 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