{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:28:10Z","timestamp":1782192490928,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oral mucositis is a common debilitating condition in patients with cancer receiving cytotoxic therapies. This study aimed to evaluate the effects of topical administrations of the essential oil extracted from hull of <jats:italic>Pistacia atlantica<\/jats:italic> fruit (bene) on healing of oral mucositis in golden hamsters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty hamsters with oral mucositis induced by 5\u2010fluorouracil administered on days 0, 5 and 10 and buccal mucosal scratching were randomly divided into four equal groups: group 1 received no additional treatment, group 2 received gel base, and groups 3 and 4 received gels containing 5% and 10% oil, respectively. From day 12, after blood sampling of all animals, a half randomly selected fraction of each group (four half groups) received once\u2010daily topical administration of either gel type (gel base, 5% and 10%) or no treatment (control subgroup) over the buccal pouches for 3 days and the remaining halves received the same treatments for 6 days. On each final day 15 and 18, the corresponding subgroups underwent consecutively the repeated blood sampling, mucosal clinical examination and excision for histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparisons on macro\u2010 and microscopical oral mucositis scorings demonstrated dose\u2010dependent healing promotion in the subgroups receiving active gels (<jats:italic>P<\/jats:italic> &lt; 0.05). The blood samplings revealed the chemotherapy\u2010related pancytopenia with no significant difference among all subgroups on either end point (<jats:italic>P<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The healing effect of the bene oil could mainly be local and attributed to its antioxidants and fatty acid contents present in non\u2010saponified and saponified fractions, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12540","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T11:21:52Z","timestamp":1481973712000},"page":"725-730","source":"Crossref","is-referenced-by-count":15,"title":["Healing acceleration of oral mucositis induced by 5\u2010fluorouracil with <i>Pistacia atlantica<\/i> (bene) essential oil in hamsters"],"prefix":"10.1111","volume":"46","author":[{"given":"Nader","family":"Tanideh","sequence":"first","affiliation":[{"name":"Stem Cell and Transgenic Technology Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Department of Pharmacology School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6225-241X","authenticated-orcid":false,"given":"Mehdy","family":"Davarmanesh","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Diagnosis School of Dentistry Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Andisheh\u2010Tadbir","sequence":"additional","affiliation":[{"name":"Oral and Dental Health Care Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Department of Oral and Maxillofacial Pathology School of Dentistry Shiraz University of Medical Sciences Shiraz 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