{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T20:36:02Z","timestamp":1781987762505,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T00:00:00Z","timestamp":1485302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oral submucous fibrosis (<jats:styled-content style=\"fixed-case\">OSF<\/jats:styled-content>) is a chronic debilitating disease and a premalignant condition of the oral cavity. It is well known for its impervious nature to medical therapy. Omega\u20103 polyunsaturated fatty acids have been reported to have anti\u2010inflammatory properties. However, its role in <jats:styled-content style=\"fixed-case\">OSF<\/jats:styled-content> is still not known. This preliminary study assessed the efficacy of systemic omega 3 in this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized single\u2010blinded controlled trial was designed, and a total of 10 clinically confirmed adult patients with <jats:styled-content style=\"fixed-case\">OSF<\/jats:styled-content> were included in the study. Group A was given biweekly intralesional injections of dexamethasone 1.5 ml and hyaluronidase 1500 IU mixed with lignocaine for 6 weeks and a placebo for 3 months. Group B was also given similar intralesional injections but with 1 gm of omega 3 three times daily continuously for 3 months. Patients were followed every month for 3 months and then after 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant improvement was noted among all clinical parameters (interincisal distance, tongue protrusion, cheek flexibility, and visual analogue scale) in both the groups. Intergroup comparison showed significant reduction in burning sensation in group B; that is, <jats:italic>P<\/jats:italic> value was 0.005, while improvement in rest of the three clinical features was not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Omega 3 can be used as an adjunctive treatment option in patients with <jats:styled-content style=\"fixed-case\">OSF<\/jats:styled-content> to reduce subjective symptoms. More studies should be conducted with a larger sample size to study the effect of omega 3 in patients with <jats:styled-content style=\"fixed-case\">OSF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12542","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T19:14:14Z","timestamp":1482866054000},"page":"439-442","source":"Crossref","is-referenced-by-count":7,"title":["Omega 3: a novel treatment agent in oral submucous fibrosis: a pilot study"],"prefix":"10.1111","volume":"46","author":[{"given":"Milanjeet Kaur","family":"Raizada","sequence":"first","affiliation":[{"name":"Oral Medicine &amp; Radiology Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Digamber M","family":"Sable","sequence":"additional","affiliation":[{"name":"Oral Medicine &amp; Radiology Dr. D. Y. Patil Dental College &amp; Hospital DPU Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Chowdhery","sequence":"additional","affiliation":[{"name":"Department of Oral and Medicine &amp; Radiology Dr. D. Y. Patil Dental College and Hospital Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh Shivaji","family":"Chavan","sequence":"additional","affiliation":[{"name":"Oral Medicine and Radiology Dr. D. Y. Patil Dental College Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladu Singh","family":"Rajpurohit","sequence":"additional","affiliation":[{"name":"Department of Public health dentistry Dr. D.Y.Patil Dental College &amp; Hospital DPU Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00325.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.08.005"},{"key":"e_1_2_6_4_1","first-page":"58","article-title":"lycopene in the management of oral submucous fibrosis","volume":"6","author":"Selvam NP","year":"2013","journal-title":"Asian J Pharm Clin Res"},{"key":"e_1_2_6_5_1","first-page":"996","article-title":"Drug treatment of oral sub mucous fibrosis \u2013 A Review","volume":"3","author":"Chole RH","year":"2016","journal-title":"Int J Contemp Med Res"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.09.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665108008690"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700289"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2010.01336.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330607"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgt257"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.98970"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920415)69:8<2011::AID-CNCR2820690802>3.0.CO;2-B"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0904-2512.2004.00116.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10011-1277"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1994.tb00258.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000057393.97337.AE"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/2278-330X.114131"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/2278-330X.114134"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941738108326978"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.5812\/numonthly.9384"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt174"},{"key":"e_1_2_6_23_1","first-page":"561","article-title":"Prostate cancer risk and omega 3 fatty acid intake from fish oil\u2010A closer look at media messages versus research findings","volume":"38","author":"Alexander W","year":"2013","journal-title":"Contro Pract"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T20:06:28Z","timestamp":1696277188000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,25]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/jop.12542"],"URL":"https:\/\/doi.org\/10.1111\/jop.12542","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,25]]}}}