{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:30:59Z","timestamp":1761823859568,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T00:00:00Z","timestamp":1485561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Objectives<\/jats:title>To compare histologically and imaginologically the bone structure of rats' mandibles treated with bisphosphonates (BP<\/jats:styled-content>s) and rats that did not receive BP<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirty\u2010four rat specimens (Rattus novergicus<\/jats:italic>, Wistar strain) were divided into three groups: (i) 12 rats treated with zoledronic acid; (ii) 12 rats treated with clodronate; and (iii) the control group, containing 10 rats that received saline solution. All individuals were exposed to cone beam computed tomography (CBCT<\/jats:styled-content>). The images were processed and analyzed to obtain the Hounsfield scores, using the software OsiriX 7.0. Sixty\u2010eight histological slides were obtained from the specimens and stained with hematoxylin and eosin (HE<\/jats:styled-content>). Using the software Adobe Photoshop CS<\/jats:styled-content>6, the histological areas containing non\u2010vital bone were identified and quantified.<\/jats:p><\/jats:sec>Results<\/jats:title>Non\u2010vital bone presented positive association with the zoledronic acid and clodronate groups. Statistically, no significant difference in bone density was observed among the groups.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Based on the results, the BP<\/jats:styled-content> therapy alone was sufficient to induce osteonecrosis. In addition, the CBCT<\/jats:styled-content> was not a sensible method for detection of the early signs of bone modification in individuals under BP<\/jats:styled-content> therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12546","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T07:02:43Z","timestamp":1483599763000},"page":"632-636","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of effects of zoledronic acid and clodronate on the bone structure: imaginological and histomorphometrical study in vivo<\/i>"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1842-1834","authenticated-orcid":false,"given":"Stephanie Joana Roman","family":"Martelli","sequence":"first","affiliation":[{"name":"Graduate Program in Dentistry Federal University of Pelotas Pelotas RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa Feres","family":"Damian","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry Federal University of Pelotas Pelotas RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula Neutzling","family":"Gomes","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry Federal University of Pelotas Pelotas RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Ribeiro","family":"Schinestsck","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry Federal University of Pelotas Pelotas RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Em\u00eddio Ribeiro","family":"Silva","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry Federal University of Pelotas Pelotas RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Uchoa","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Graduate Program in Dentistry Federal University of Pelotas Pelotas RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/99102700"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/192320"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.01.014"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2023H"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2007.07.005"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2015.06.002"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2405"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2015.06.008"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-014-1951-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.01.012"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.8.667"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2013.11.005"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21422"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01140.x"},{"key":"e_1_2_5_17_1","unstructured":"MacerataR.Zometa (zoledronic acid)\u2014intravenous formulation. 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