{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:41:58Z","timestamp":1783780918137,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,1,28]],"date-time":"2017-01-28T00:00:00Z","timestamp":1485561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oxidative stress (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) has been thought to play a main role in the etiopathogenesis of recurrent aphthous stomatitis (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>), which is one of the most common oral mucosal diseases characterized by recurrent and painful oral ulcers. The aim of this investigation was to evaluate the enzymatic antioxidants status in patients with <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> in the active stage and remission stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010seven patients with idiopathic minor <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> and 102 race\u2010, age\u2010 and gender\u2010matched healthy individuals were recruited. All these subjects were allocated to three groups: <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> patients with active lesion (group A); the same patients in group A in the remission stage of <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> (group B); and healthy individuals without <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> (group C). Following an overnight fast, blood samples were obtained. The serum levels of superoxide dismutase (<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>), catalase (<jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content>), and glutathione peroxidase (<jats:styled-content style=\"fixed-case\">GSHP<\/jats:styled-content>x) were measured by the spectrophotometric method. Independent\u2010samples <jats:italic>t<\/jats:italic>\u2010test and paired <jats:italic>t<\/jats:italic>\u2010test were performed for statistical evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum levels of <jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GSHP<\/jats:styled-content>x, and <jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content> (83.9 \u00b1 17.1 U\/ml, 6687.2 \u00b1 2629.2 U\/ml, 1789.7 \u00b1 593.8 U\/l) were found to be significantly lower in group A as compared to those of group B (99.8 \u00b1 11.1 U\/ml, 9364.1 \u00b1 1607.9 U\/ml, 2789.1 \u00b1 1113.4 U\/l; <jats:italic>P<\/jats:italic> &lt; 0.05) or group C (97.3 \u00b1 12.1 U\/ml, 9246.2 \u00b1 2376.1 U\/ml, 2819.0 \u00b1 914.8 U\/l; <jats:italic>P<\/jats:italic> &lt; 0.05). No significant differences were found between group B and group C with respect to any one of these enzymatic antioxidants (<jats:italic>P<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that enzymatic antioxidant defense system is impaired in <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> patients with active lesion and seems to play a crucial role in its pathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12547","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T07:02:42Z","timestamp":1483599762000},"page":"817-820","source":"Crossref","is-referenced-by-count":18,"title":["Enzymatic antioxidants status in patients with recurrent aphthous stomatitis"],"prefix":"10.1111","volume":"46","author":[{"given":"Zichuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Stomatology Bethune International Peace Hospital Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Outpatient Bethune Military Medical School Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Bethune International Peace Hospital Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01143.x"},{"key":"e_1_2_5_3_1","first-page":"95","article-title":"Recurrent aphthous stomatitis","volume":"31","author":"Ship JA","year":"2000","journal-title":"Quintessence Int"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/ijom.2002.0446"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01134.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01197.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2013.34158"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.18110"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12084"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2004.00253.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13101"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01466.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2013.25.3.273"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.15.e557"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-1181-2"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.04.005"},{"key":"e_1_2_5_17_1","first-page":"13","article-title":"Salivary oxidant\/antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis","volume":"7","author":"Babaee N","year":"2016","journal-title":"Caspian J Intern Med"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.206.305"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/340819"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01415.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01488.x"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12547","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T15:41:36Z","timestamp":1694274096000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,28]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/jop.12547"],"URL":"https:\/\/doi.org\/10.1111\/jop.12547","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,28]]}}}