{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:51:03Z","timestamp":1792687863729,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371147"],"award-info":[{"award-number":["81371147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T\u2010helper cell is crucial for the inflammatory autoimmune condition of oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>). Recently, the pathogenetic functions of T follicular helper (Tfh) cells, a subtype of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T\u2010helper cells, have been revealed in autoimmune diseases for their pivotal regulation on humoral immunity. To explore the potential pathophysiological role of Tfh cells in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>, the expression of circulating Tfh\u2010like cells and its correlations with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 and B cells were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The frequencies of <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>5<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> Tfh\u2010like cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19<jats:sup>+<\/jats:sup> B cells were analyzed in peripheral blood of patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and controls by flow cytometry, respectively. Besides, the serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 concentration was measured using <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> technology. Furthermore, the correlations of <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>5<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> Tfh\u2010like cells with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19<jats:sup>+<\/jats:sup> B cells and serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 expression levels were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study showed significant increased circulating Tfh\u2010like cells (<jats:italic>P<\/jats:italic> &lt; 0.05) and B cells (<jats:italic>P<\/jats:italic> &lt; 0.0001), as well as decreased serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 expression (<jats:italic>P<\/jats:italic> &lt; 0.001) in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. Besides, the frequency of Tfh\u2010like cells exhibited negative correlation with B cells in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> (<jats:italic>r<\/jats:italic> = \u22120.435, <jats:italic>P<\/jats:italic> &lt; 0.05). In particular, the proportion of <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>5<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> Tfh\u2010like cells in peripheral blood mononuclear cells of erosive <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> was higher than non\u2010erosive <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and controls (<jats:italic>P<\/jats:italic> = 0.012 and 0.021, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased circulating Tfh\u2010like cells may be involved in the pathogenesis of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> through abnormal modulation on B\u2010cell proliferation and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 production, and associated with different clinical forms of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12550","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T18:05:24Z","timestamp":1485367524000},"page":"803-809","source":"Crossref","is-referenced-by-count":19,"title":["Increased circulating <scp>CXCR<\/scp>5<sup>+<\/sup><scp>CD<\/scp>4<sup>+<\/sup> T follicular helper\u2010like cells in oral lichen planus"],"prefix":"10.1111","volume":"46","author":[{"given":"Ya\u2010Qin","family":"Tan","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral Medicine School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge\u2010Fei","family":"Du","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral Medicine School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Lu","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral Medicine School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhou","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral Medicine School and Hospital of Stomatology Wuhan University Wuhan 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