{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:40:05Z","timestamp":1790959205876,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Background<\/jats:title>The aim of this study was to compare the clinicopathological features of oral squamous cell carcinoma in the background of oral submucous fibrosis (OSCC<\/jats:styled-content>\u2010OSMF<\/jats:styled-content>) and oral squamous cell carcinoma (OSCC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 217 cases ofOSCC<\/jats:styled-content>were retrieved from achieves for the analysis.OSCC<\/jats:styled-content>\u2010OSMF<\/jats:styled-content>cases were segregated on the basis of history and clinicopathological parameters.<\/jats:p><\/jats:sec>Results<\/jats:title>The study included 217 patients of which 112 hadOSCC<\/jats:styled-content>and 105OSCC<\/jats:styled-content>\u2010OSMF<\/jats:styled-content>.OSCC<\/jats:styled-content>\u2010OSMF<\/jats:styled-content>s were younger compared withOSCC<\/jats:styled-content>. Overall oral cancer was noted predominantly in males compared to females. The number ofOSCC<\/jats:styled-content>\u2010OSMF<\/jats:styled-content>was more in clinicalTNM<\/jats:styled-content>stage I and stageII<\/jats:styled-content>as compared toOSCC<\/jats:styled-content>, whereas the number ofOSCC<\/jats:styled-content>was more in stageIII<\/jats:styled-content>and stageIV<\/jats:styled-content>compared toOSCC<\/jats:styled-content>\u2010OSMF<\/jats:styled-content>. Histological presentation of well\u2010differentiated squamous cell carcinoma was significantly more inOSCC<\/jats:styled-content>\u2010OSMF<\/jats:styled-content>compared toOSCC<\/jats:styled-content>, whereas moderately differentiated squamous cell carcinoma was significantly more inOSCC<\/jats:styled-content>compared toOSCC<\/jats:styled-content>\u2010OSMF<\/jats:styled-content>. Regional lymph node metastasis was significantly higher inOSCC<\/jats:styled-content>compared toOSCC<\/jats:styled-content>\u2010OSMF<\/jats:styled-content>. Three\u2010year disease\u2010free survival rate was significantly higher inOSCC<\/jats:styled-content>\u2010OSMF<\/jats:styled-content>compared toOSCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>TheOSCC<\/jats:styled-content>\u2010OSMF<\/jats:styled-content>was found to be a clinicopathologically distinct entity with a better grade of tumor differentiation, less incidence of nodal metastases, and early detection (early clinicalTNM<\/jats:styled-content>stage) compared to OSCC. All these factors probably contribute to a better prognosis and increased 3\u2010year disease\u2010free survival in OSCC\u2010OSMF patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12553","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T21:33:23Z","timestamp":1485552803000},"page":"448-453","source":"Crossref","is-referenced-by-count":73,"title":["Oral squamous cell carcinoma in the background of oral submucous fibrosis is a distinct clinicopathological entity with better prognosis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-7694","authenticated-orcid":false,"given":"Amol Ramchandra","family":"Gadbail","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology & Microbiology Sharad Pawar Dental College & Hospital Datta Meghe Institute of Medical Sciences Wardha Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minal","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology & Microbiology Sharad Pawar Dental College & Hospital Datta Meghe Institute of Medical Sciences Wardha Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuri","family":"Gawande","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology & Microbiology Sharad Pawar Dental College & Hospital Datta Meghe Institute of Medical Sciences Wardha Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka","family":"Hande","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology & Microbiology Sharad Pawar Dental College & Hospital Datta Meghe Institute of Medical Sciences Wardha Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1856-0957","authenticated-orcid":false,"given":"Sachin","family":"Sarode","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology & Microbiology Dr. D.Y. 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