{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:02:44Z","timestamp":1774897364000,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to analyse the incidence of lip malignancies in Germany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from population\u2010based cancer registries covering a population of 39 million inhabitants from 14 federal states were pooled. Lip malignancies were classified according to the International Classification of Diseases (<jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u201010). Age\u2010standardised incidence rates and annual percentage changes in the incidence trends of lip cancer (C00), melanoma of the lip (C43.0), and non\u2010melanoma skin cancer of the lip (C44.0) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lip cancer (C00) incidence rate was 0.57\/0.15 per 100 000 (men\/women) in 2003 and 0.52\/0.18 in 2012. In women, the change was statistically significant.<\/jats:p><jats:p>Melanoma lip cancer (C43.0) incidence rates both in men and women were 0.02 in 2003 and 0.01 in 2012. Incidence rates of non\u2010melanoma skin cancer of the lip (C44.0) significantly increased from 1.6 in 2003 to 2.1 in 2012 in men and from 1.5 in 2003 to 2.4 in 2012 in women.<\/jats:p><jats:p>In lip cancer (C00), the vast majority (98% in men\/93% in women) were squamous cell carcinomas and 2%\/7% were basal cell carcinoma. In men, 56% of non\u2010melanoma skin cancers (C44.0) were squamous cell carcinoma, whereas these were only 27% in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidences of non\u2010melanoma skin cancer of the lip increased over time in Germany in both sexes. Lip cancer incidence increased in women, while it stayed stable in men. Melanoma of the lip did not change in incidence. The distribution of histology in non\u2010melanoma skin cancer of the lip differed by sex.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12559","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T23:32:39Z","timestamp":1486596759000},"page":"780-785","source":"Crossref","is-referenced-by-count":10,"title":["Incidence of lip malignancies in Germany\u2014data from nine population\u2010based cancer registries"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-7964","authenticated-orcid":false,"given":"Susanne","family":"Singer","sequence":"first","affiliation":[{"name":"Institute of Medical Biostatistics Epidemiology and Informatics University Medical Centre Johannes Gutenberg University Mainz Mainz Germany"},{"name":"University Cancer Centre Mainz (UCT) Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylke Ruth","family":"Zeissig","sequence":"additional","affiliation":[{"name":"Institute of Medical Biostatistics Epidemiology and Informatics University Medical Centre Johannes Gutenberg University Mainz Mainz Germany"},{"name":"Cancer Registry Rhineland\u2010Palatinate Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Emrich","sequence":"additional","affiliation":[{"name":"Institute of Medical Biostatistics Epidemiology and Informatics University Medical Centre Johannes Gutenberg University Mainz Mainz Germany"},{"name":"Cancer Registry Rhineland\u2010Palatinate Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Holleczek","sequence":"additional","affiliation":[{"name":"Saarland Cancer Registry Saarbr\u00fccken Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Kraywinkel","sequence":"additional","affiliation":[{"name":"German Centre of Cancer Registry Data Department of Epidemiology &amp; Health Monitoring Robert Koch Institute Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meike","family":"Ressing","sequence":"additional","affiliation":[{"name":"Institute of Medical Biostatistics Epidemiology and Informatics University Medical Centre Johannes Gutenberg University Mainz Mainz Germany"},{"name":"Cancer Registry Rhineland\u2010Palatinate Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn044"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.06.013"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3415-6"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12010"},{"key":"e_1_2_5_6_1","first-page":"451","article-title":"Ver\u00e4nderung von Inzidenz und Mortalit\u00e4t von Kopf\u2010Hals\u2010Malignomen in Rheinland\u2010Pfalz in den Jahren 2000\u20102009","volume":"94","author":"Bayer O","year":"2015","journal-title":"Laryngorhinootologie"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1993.tb00774.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290702.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-7563.2008.00157.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09698.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.03.008"},{"key":"e_1_2_5_12_1","first-page":"S23","article-title":"The time trends of incidence of lip cancer and cutaneous melanoma by sun exposure in the SEER 9 registries, 1973\u20131996","volume":"12","author":"Park H","year":"2001","journal-title":"Epidemiology"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1999.tb00300.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.17501"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.01.003"},{"key":"e_1_2_5_16_1","volume-title":"TNM classification of malignant tumours","author":"Sobin LH","year":"2009"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588414X14055925061676"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)00029-3"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600975"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00052672"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2009.00493.x"},{"key":"e_1_2_5_22_1","volume-title":"Statistisches Jahrbuch (Annual Report)","author":"Statistisches Bundesamt","year":"2015"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(98)80010-6"},{"key":"e_1_2_5_24_1","first-page":"438","article-title":"Gender differences in subjective help seeking threshold and health care utilization: is there an interrelation between both features?","volume":"43","author":"Glaesmer H","year":"2008","journal-title":"Int J Psychol"}],"container-title":["Journal of Oral Pathology &amp; 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