{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:49:06Z","timestamp":1781246946758,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 103\u20102632\u2010B\u2010040\u2010001"],"award-info":[{"award-number":["MOST 103\u20102632\u2010B\u2010040\u2010001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Background<\/jats:title>Oral submucous fibrosis (OSF<\/jats:styled-content>) is one of the well\u2010recognized oral potentially malignant disorders. In this study, we investigated the malignant transformation of OSF<\/jats:styled-content> in a Taiwanese population.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. A comparison cohort was randomly frequency\u2010matched with the OSF<\/jats:styled-content> cohort according to age, sex, and index year. Oral leukoplakia (OL<\/jats:styled-content>) was further stratified to evaluate for the possible synergistic effects of OSF<\/jats:styled-content>\u2010associated malignant transformation.<\/jats:p><\/jats:sec>Results<\/jats:title>In this cohort, 71 (9.13%) of 778 cases of OSF<\/jats:styled-content> were observed to transform into oral cancer. The malignant transformation rate was 29.26\u2010fold in the OSF<\/jats:styled-content> cohort than in the comparison cohort after adjustment (95% confidence intervals 20.55\u201041.67). To further stratify with OL, OSF<\/jats:styled-content> with OL<\/jats:styled-content> (52.46%; 95% confidence intervals 34.88\u201078.91) had higher risk of malignant transformation rate than OSF<\/jats:styled-content> alone (29.84%; 95% confidence intervals 20.99\u201042.42). The Kaplan\u2010Meier plot revealed the rate free of malignant transformation was significant over the 13\u2010year follow\u2010up period (log\u2010rank test, P<\/jats:italic><.001). The mean duration of malignant transformation was 5.1, 2.7, and 2.2\u00a0years for non\u2010OSF<\/jats:styled-content>, OSF<\/jats:styled-content> alone, and OSF<\/jats:styled-content> with OL<\/jats:styled-content>, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Oral submucous fibrosis patients exhibited a significantly higher risk of malignant transformation than those without OSF<\/jats:styled-content>. OL<\/jats:styled-content> could enhance malignant transformation in patients with OSF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12570","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T21:25:29Z","timestamp":1489526729000},"page":"1040-1045","source":"Crossref","is-referenced-by-count":62,"title":["Malignant transformation of oral submucous fibrosis in Taiwan: A nationwide population\u2010based retrospective cohort study"],"prefix":"10.1111","volume":"46","author":[{"given":"Po\u2010Yu","family":"Yang","sequence":"first","affiliation":[{"name":"School of Dentistry Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Dentistry Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Tzu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dentistry Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hsun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni\u2010Yu","family":"Su","sequence":"additional","affiliation":[{"name":"School of Dentistry Chung Shan Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Chieh","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Dentistry Chung Shan Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9731-2577","authenticated-orcid":false,"given":"Yu\u2010Chao","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Dentistry Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Dentistry Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.08.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13556210020091437"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1985.tb00468.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00485.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.04.013"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.10.014"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00491.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-14-99"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.12.004"},{"key":"e_1_2_7_12_1","unstructured":"National Health Insurance Administration Ministry of Health and Welfare Taiwan R.O.C.National health insurance annual report 2014\u20102015."},{"key":"e_1_2_7_13_1","unstructured":"National health insurance research database. 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