{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:17:10Z","timestamp":1759515430698,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T00:00:00Z","timestamp":1493337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672745"],"award-info":[{"award-number":["81672745"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["15411950300"],"award-info":[{"award-number":["15411950300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Platelet\u2010derived growth factors alpha (<jats:styled-content style=\"fixed-case\">PDGFA<\/jats:styled-content>) is a tyrosine kinase receptor activator which is known to be amplified in the malignancies, and their expression levels are correlated to tumor progression and reduced overall survival. The expression of <jats:styled-content style=\"fixed-case\">PDGFRA<\/jats:styled-content> is different among the tumors and normal tissues; furthermore, their expression level is site specific. Under a physiological condition, <jats:styled-content style=\"fixed-case\">PDGFRA<\/jats:styled-content> and its ligand are expressed in distinct cell populations and activated in a paracrine manner. Nevertheless, heterodimer characteristic of <jats:styled-content style=\"fixed-case\">PDGFRA<\/jats:styled-content> allows it to be trans\u2010activated by non\u2010specific ligands or via autocrine manner. The future of cancer therapy can be based on <jats:styled-content style=\"fixed-case\">PDGFRA<\/jats:styled-content> receptor blockade and therefore warrants further investigation to determine the differing expression of <jats:styled-content style=\"fixed-case\">PDGFRA<\/jats:styled-content> between controls and patients with oral squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a case\u2010control study of 111 patients with newly diagnosed tongue squamous cell carcinoma and 111 control subjects without a cancer diagnosis, matched for age and gender, to evaluate the association between <jats:styled-content style=\"fixed-case\">PDGFRA<\/jats:styled-content> expression levels in oral mucosa. We then performed smoking stratification in each cohort. Independent <jats:italic>t<\/jats:italic> test analysis was applied for case\u2010control comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean value of <jats:styled-content style=\"fixed-case\">PDGFRA mRNA<\/jats:styled-content> level (\u2212\u0394Ct) for normal cohort is \u221230.242, whereas mean value of <jats:styled-content style=\"fixed-case\">PDGFRA mRNA<\/jats:styled-content> level for patients with <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> is \u221211.516. <jats:styled-content style=\"fixed-case\">PDGFRA mRNA<\/jats:styled-content> level (\u2212\u0394Ct) was significantly higher in oral cancer cohort, <jats:italic>P<\/jats:italic>&lt;.001. Smokers have a significantly higher <jats:styled-content style=\"fixed-case\">PDGFRA mRNA<\/jats:styled-content> expression in comparison with non\u2010smokers (<jats:italic>P<\/jats:italic>=.002) among the non\u2010cancer group. Likewise, this trend is observed in cancer cohort too, <jats:italic>P<\/jats:italic>=.044.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PDGFRA<\/jats:styled-content> expression is significantly higher in oral cancer cohort with or without the establishment of tobacco risk factor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12571","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T10:08:05Z","timestamp":1490436485000},"page":"591-597","source":"Crossref","is-referenced-by-count":11,"title":["<scp>PDGFRA mRNA<\/scp> is overexpressed in oral cancer patients as compared to normal subjects with a significant trend of overexpression among tobacco users"],"prefix":"10.1111","volume":"46","author":[{"given":"Hui Shan","family":"Ong","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial\u2010Head &amp; Neck Oncology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandhya","family":"Gokavarapu","sequence":"additional","affiliation":[{"name":"Head &amp; Neck Oncology Reconstructive Surgery Department of Surgical Oncology Krishna Institute of Medical Science Hyderabad Telangana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Oral and Maxillofacial\u2010Head &amp; Neck Oncology and Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial\u2010Head &amp; Neck Oncology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4976-3637","authenticated-orcid":false,"given":"Chen Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial\u2010Head &amp; Neck Oncology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,28]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"http:\/\/www.cancerindex.org\/geneweb\/\/PDGFRA.htm. 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